Results 21 to 30 of about 191,701 (337)

The physiopathology of lipoprotein a

Frontiers in Bioscience, 2010
Lipoprotein(a) (also called Lp(a)) is a lipoprotein subclass. Different studies have identified Lp(a) as a putative risk factor for atherosclerotic diseases such as coronary artery disease and stroke. The physiological role of Lp(a) in humans is still unclear, but it seems that individuals with low concentrations of plasma Lp(a) manifest no deficiency ...
GALVANO, Fabio, MALAGUARNERA M, VACANTE M, MOTTA, Massimo, RUSSO C, MALAGUARNERA M, D'ORAZIO N, MALAGUARNERA, Lucia   +7 more
openaire   +4 more sources

A new lipid-structured model to investigate the opposing effects of LDL and HDL on atherosclerotic plaque macrophages [PDF]

arXiv, 2022
Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction between monocyte-derived macrophages and extracellular lipid. Although concentrations of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles in the blood
arxiv  

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Ramadan Fasting Model Exerts Hepatoprotective, Anti-obesity, and Anti-Hyperlipidemic Effects in an Experimentally-induced Nonalcoholic Fatty Liver in Rats [PDF]

arXiv, 2023
Background: The epidemic of nonalcoholic fatty liver disease (NAFLD) and its metabolic effects present a serious public health concern. We hypothesized that the Ramadan fasting model (RFM), which involves fasting from dawn to dusk for a month, could provide potential therapeutic benefits and mitigate NAFLD.
arxiv  

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules

Lipids in Health and Disease, 2004
Introduction Oxidative stress has been demonstrated in malaria. The potential oxidative modification of lipoproteins derived from malaria patients was studied. These oxidized lipids may have role in pathogenesis of malaria.
Looareesuwan Sornchai, Brittenham Gary, Leowattana Wattana, Krudsood Srivicha, Yamanont Paveena, Sibmooh Nathawut, Udomsangpetch Rachanee   +6 more
doaj   +1 more source

Biophysicochemical interaction of a clinical pulmonary surfactant with nano-alumina [PDF]

Langmuir 31 (26) 7346 - 7354 (2015), 2015
We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity. We study the bulk properties of phospholipid/nanoparticle dispersions and determine the nature of their interactions.
arxiv   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Comparative investigation on the sizes and scavenger receptor binding of human native and modified lipoprotein particles with atomic force microscopy

Journal of Nanobiotechnology, 2018
Background The size and receptor-binding abilities of plasma lipoproteins are closely related with their structure/functions. Presently, the sizes of native lipoproteins have been measured by various methods including atomic force microscopy (AFM ...
Chaoye Gan, Kun Wang, Qisheng Tang, Yong Chen   +3 more
doaj   +1 more source

Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein

Frontiers in Immunology, 2021
IntroductionDuring peritonitis, lipopolysaccharides (LPS) cross the peritoneum and pass through the liver before reaching the central compartment. The aim of the present study was to investigate the role of lipoproteins and phospholipid transfer protein (
Maxime Nguyen, Maxime Nguyen, Maxime Nguyen, Maxime Nguyen, Gaëtan Pallot, Gaëtan Pallot, Antoine Jalil, Antoine Jalil, Annabelle Tavernier, Annabelle Tavernier, Aloïs Dusuel, Aloïs Dusuel, Naig Le Guern, Naig Le Guern, Laurent Lagrost, Laurent Lagrost, Laurent Lagrost, Jean-Paul Pais de Barros, Jean-Paul Pais de Barros, Hélène Choubley, Hélène Choubley, Victoria Bergas, Victoria Bergas, Pierre-Grégoire Guinot, Pierre-Grégoire Guinot, Pierre-Grégoire Guinot, Pierre-Grégoire Guinot, David Masson, David Masson, David Masson, David Masson, Belaid Bouhemad, Belaid Bouhemad, Belaid Bouhemad, Belaid Bouhemad, Thomas Gautier, Thomas Gautier, Thomas Gautier   +37 more
doaj   +1 more source