Results 41 to 50 of about 1,901 (164)

Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prolonged pain relief in in vivo rat models

Scientific Reports, 2021
To efficiently prolong analgesic effects, we developed osmotically balanced, large unilamellar liposomes (~ 6 μm in diameter) in which highly concentrated bupivacaine (up to 30 mg/mL) was encapsulated, and their sustained bupivacaine release was highly ...
Hyebin Yoo, Jun Seok Park, Seung Soo Oh, Hyun Kang   +3 more
doaj   +1 more source

Wound infiltration with local anesthetics during cesarean delivery with intrathecal opioids: A systematic review and meta‐analysis of randomized control trials

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Objective To evaluate the effect on maternal pain of local anesthetic wound infiltration for intra‐cesarean delivery analgesia in patients who also received intrathecal opioids Data sources Scopus, PubMed, and Cochrane Central Register of Controlled Trials were searched from the inception of each database to August 2023.
Valentina Frusone, Kavisha Khanuja, Jacqueline Sinnott, Valentina Bellussi, Guillaume Ducarme, Manuel Gomez‐Rios, Jerome Rosetti, Amanda Roman, Vincenzo Berghella   +8 more
wiley   +1 more source

Digital hamartoma resulting in a gait abnormality in a dog

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 9‐year‐old Brussels Griffon presented for assessment of a pendulous mass on the dorsal aspect of the third digit of the left hindlimb, following prior trauma to the area during a grooming visit. The primary veterinarian performed a fine needle aspirate of the mass, which revealed a mixed population of inflammatory cells. At presentation, the
Tenley R. Porcher, Laura E. Selmic
wiley   +1 more source

Study of Peri-Articular Anaesthetic for Replacement of the Knee (SPAARK): study protocol for a patient-blinded, randomised controlled superiority trial of liposomal bupivacaine

Trials, 2019
Background Optimising the management of peri-operative pain and recovery following knee replacement has been identified as a patient priority. Current pain relief strategies use opiate-based analgesia; however, up to 50% of patients experience ...
Ruth Knight, Lisa Poulton, Louise H. Strickland, Thomas W. Hamilton, David Beard, Jonathan Cook, Susan J. Dutton, Jose Leal, Sarah Lamb, Cushla Cooper, Karen L. Barker, David W. Murray, Hemant G. Pandit   +12 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Noninferiority of Ultrasound‐Guided Modified Intercostal Block to Traditional Approach for Analgesia After Minimally Invasive Repair of Pectus Excavatum in Children: A Randomized Trial

Pain Research and Management, Volume 2026, Issue 1, 2026.
Background For pediatric pectus excavatum, the standard treatment is minimally invasive repair of pectus excavatum (MIRPE). A major challenge, however, is the severe postoperative pain. Although ultrasound‐guided intercostal nerve block (UINB) offers effective analgesia, the technique’s complexity and associated safety concerns are significant barriers,
Ming-Wen Yang, Xian-Lun Duan, Yu-Zhu Cai, Yin Xia, Ying-Ying Sun, Xin-Qi Cheng, Hui Lu   +6 more
wiley   +1 more source

Research Trends in Pain Management After Thoracoscopic Surgery (2015–2024): A Bibliometric Analysis

Pain Research and Management, Volume 2026, Issue 1, 2026.
Background Thoracoscopic surgery, a representative minimally invasive approach in thoracic surgery, is increasingly employed. However, postoperative pain remains a significant barrier to recovery and quality of life. We aimed to quantitatively analyze research on postoperative pain following thoracoscopic surgery over the past decade; to identify the ...
Dezhou Jiang, Funing Liu, Zehao Liu, Jun Peng, Yan Liu, Yan Weng, Run Wang, Qing Zhong, Alessandro Vittori   +8 more
wiley   +1 more source

Long-term sensorimotor changes after a sciatic nerve block with bupivacaine and liposomal bupivacaine in a high-fat diet/low-dose streptozotocin rodent model of diabetes

Frontiers in Anesthesiology
IntroductionIt is unclear whether patients with diabetes are more susceptible to nerve toxicity of local anesthetics or whether nerve blocks can accelerate the progression of diabetic peripheral neuropathy.
Susanna C. Byram, Susanna C. Byram, Susanna C. Byram, Susanna C. Byram, Krista M. Lotesto, Krista M. Lotesto, Michael Volyanyuk, Michael Volyanyuk, Jacob E. Exline, Jacob E. Exline, Elizabeth A. Sager, Eileen M. Foecking, Eileen M. Foecking, Eileen M. Foecking, Eileen M. Foecking, Eileen M. Foecking   +15 more
doaj   +1 more source

Topical versus oral metronidazole for post‐haemorrhoidectomy pain: A systematic review and meta‐analysis of randomized controlled trials

Colorectal Disease, Volume 27, Issue 12, December 2025.
Abstract Background Excisional haemorrhoidectomy is often associated with intense post‐operative pain and delayed recovery. Bacterial colonization may contribute to this discomfort, and metronidazole has been proposed as an analgesic adjunct. This study compared the analgesic efficacy of topical metronidazole with oral metronidazole.
Bernardo Fontel Pompeu, Giulia Luiza Garcia, Gabriel Leal Barone, Isabela Oliveira Rosa, Lucas Soares de Souza Pinto Guedes, Lucas Monteiro Delgado, Claudia Theis, Leonardo de Melo Del Grande, Sergio Mazzola Poli de Figueiredo, Fernanda Bellotti Formiga   +9 more
wiley   +1 more source

Innovative Applications of Marine Macroalgae Polysaccharides in Tissue Engineering and Drug Delivery: A Review Study

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims Marine macroalgae are abundant sources of bioactive polysaccharides—including alginate, fucoidan, ulvan, carrageenan, and agarose—widely recognized for extensive biomedical applications. These polysaccharides exhibit remarkable biological properties, such as immunostimulatory, anticancer, antioxidant, antimicrobial, and ...
Foroozan Jalalibidgoli, Pardis Irankhahi, Helia Hajihassani, Ali Akbar Ghotbi‐Ravandi   +3 more
wiley   +1 more source