Results 71 to 80 of about 2,540 (202)
PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
MedComm, Volume 6, Issue 8, August 2025.The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang +10 more
wiley +1 more source
, 2012 Analjezik etki sürelerini uzatmak, toksisitelerini azaltmak amacıyla lokal anestezikler lipozomlarla enkapsüle edilmektedir. Bu çalışmada multilameller lipozomal bupivakainin farklı formlarını hazırlayarak yapay beyin omurilik sıvısı (BOS) içerisindeki ...
Düzlü, Ayşe
core
Liposomal bupivacaine—a new tool in our armamentarium? [PDF]
Annals of Joint, 2016 Almost two decades on from when Enhanced Recovery Programs (ERPs), consisting of multi-modal therapies to reduce surgical stress, were first proposed by Kehlet et al. the complexity of ERPs has increased, with interventions now utilized pre-, intra- and post-operatively (1). Whilst the use of ERPs has been demonstrated to significantly reduce patient
Hamilton, TW, Pandit, HG
openaire +2 more sources
A dose-response study of epidural liposomal bupivacaine in rabbits
, 1999 Liposomes are drug delivery systems used to prolong local effects of bupivacaine. We studied the relationships between motor and hemodynamic changes and epidural doses of plain bupivacaine (P) and liposomal bupivacaine (L) in rabbits equipped with ...
Le Corre, Pascal +6 more
core +1 more source
Onset and duration of liposomal bupivacaine in Holstein calves using a cornual nerve block
, 2020 Dairy calves are routinely disbudded during their first few weeks of life in order to prevent injuries and provide safety for their handlers. Disbudding is a procedure that removes the calves’ horn buds and activates nociceptors and causes acute pain and
Gomez, Selena
core +1 more source
, 2021 Study objective: To evaluate the pharmacokinetics and safety of liposomal bupivacaine in pediatric patients undergoing spine or cardiac surgery. Design: Multicenter, open-label, phase 3, randomized trial (PLAY; NCT03682302).
Horn, Nicole D. +8 more
core +1 more source
, 2018 B Wycke Baker,1–4 Lea G Villadiego,1,2 Y Natasha Lake,1,2 Yazan Amin,3 Audra E Timmins,3 Laurie S Swaim,3 David W Ashton3 1Department of Obstetrical and Gynecological Anesthesiology, Texas Children’s Hospital Pavilion for Women, Houston, TX ...
Villadiego LG +6 more
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Impact of intercostal nerve blocks using liposomal versus standard bupivacaine on length of stay in minimally invasive thoracic surgery patients. [PDF]
, 2018 BACKGROUND: Postsurgical pain control can have a significant impact on patient outcomes and hospital-associated costs. We sought to evaluate the effect of intercostal nerve blocks using liposomal bupivacaine on length of stay (LOS) in patients undergoing
Ely, Sora +4 more
core +1 more source
, 2023 ObjectiveTo determine whether bupivacaine liposomal injectable suspension (BLIS) supports microbial growth when artificially inoculated and to evaluate liposomal stability in the face of this extrinsic contamination as evidenced by changes in free ...
Catherine Gensler +5 more
core +1 more source
Journal of Pain ResearchDong Xu Chen,1,2,* Xuan Ming Chen,3,* Shou Ming Chen,1,2 Yi Da Wang3 1Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Key Laboratory of Birth Defects and Related Diseases of ...
Chen DX, Chen XM, Chen SM, Wang YD
doaj