Results 261 to 270 of about 28,679 (286)

Hypothalamic lipotoxicity and the metabolic syndrome

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
Ectopic accumulation of lipids in peripheral tissues, such as pancreatic beta cells, liver, heart and skeletal muscle, leads to lipotoxicity, a process that contributes substantially to the pathophysiology of insulin resistance, type 2 diabetes, steatotic liver disease and heart failure.
Martínez de Morentin, Pablo B., Varela, Luis, Fernø, Johan, Nogueiras, Rubén, Diéguez, Carlos, López, Miguel   +5 more
openaire   +2 more sources

Ceramides in insulin resistance and lipotoxicity

Progress in Lipid Research, 2006
Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and the liver, and researchers have recently proposed two mechanisms by which excess adiposity antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their storage capacity, fat begins to accumulate in tissues not suited for lipid ...
openaire   +2 more sources

Insulin Resistance, Obesity and Lipotoxicity

2017
Lipotoxicity , originally used to describe the destructive effects of excess fat accumulation on glucose metabolism, causes functional impairments in several metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle.
Dilek, Yazıcı, Havva, Sezer
openaire   +2 more sources

Osteosarcopenia as a Lipotoxic Disease

2019
This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies.
Ahmed Al Saedi, Craig A. Goodman, Damian E. Myers, Alan Hayes, Gustavo Duque   +4 more
openaire   +1 more source

Special issue on lipotoxicity

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
A, Vidal-Puig, Roger H, Unger
openaire   +2 more sources

Insulin Resistance, Obesity, and Lipotoxicity

Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on glucose metabolism, causes functional impairments in several metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas, and muscle.
Dilek, Yazıcı, Selin Çakmak, Demir, Havva, Sezer   +2 more
openaire   +2 more sources

Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice

Diabetologia, 2023
Jianming Li, Xianyu Li, Lawrence W C Chan   +2 more
exaly  

Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death

Autophagy, 2022
Karla K Frietze, Joseph T Nickels
exaly  

Obesity and Lipotoxicity

2017
ENGİN, AYŞE BAŞAK, ENGİN, ATİLLA
  +8 more sources

SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity

Autophagy, 2020
Da Hyun Lee, Jeong Su Park, Yu Seol Lee
exaly