Results 201 to 210 of about 100,547 (310)

Correction: Disruption of Swell1/VRAC function impairs initial hemodynamics and activates compensatory leukotriene signaling in zebrafish circulation development. [PDF]

Front Cell Dev Biol
Frontiers Production Office.
europepmc   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, Volume 13, Issue 22, 17 April 2026.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Design, synthesis, characterization, biological investigation and docking studies of newly synthesized sulphonyl hydrazide and their derivatives. [PDF]

Sci Rep
Rahman M, Zafar R, Jan MS, Darwish HW, Khattak H, Aschner M, Daglia M, Khan H.   +7 more
europepmc   +1 more source

A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract Anti‐amyloid therapies for Alzheimer's disease (AD) modestly slow cognitive decline but carry significant risk of amyloid‐related imaging abnormalities (ARIAs), brain swelling, and hemorrhage, particularly in apolipoprotein E ε4 carriers. Cerebral amyloid angiopathy (CAA) and vascular inflammation drive this vulnerability, highlighting the ...
Ambreen Kanwal, Bilal E. Kerman, Shaowei Wang, Kevin Camey, Boyang Li, Lisi Flores‐Aguilar, Nada Ali, Laura Beth McIntire, Chang April Shu, Stan G. Louie, Elizabeth Head, Zoe Arvanitakis, Hussein N. Yassine   +12 more
wiley   +1 more source

Erratum: Towards Precision Treatment of Chronic Obstructive Pulmonary Disease Exacerbations: The Role of Specialized Proresolving Mediators. [PDF]

Am J Respir Crit Care Med
europepmc   +1 more source

Metabolite correlation-based network analysis combined with machine learning techniques highlights LOX biosynthesis in Vanilla planifolia and Vanilla pompona source leaves. [PDF]

Sci Rep
Toubiana D, Moon P, Bassil E, Maruenda H.   +3 more
europepmc   +1 more source

Ferroptotic neurodegeneration and diet: a narrative review

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Dietary regimes and separate components have been reported to reduce ferroptosis by (1) altering iron metabolism, (2) increasing antioxidant defense, and (3) reducing lipid peroxidation. This ultimately leads to reduced ferroptosis and neurodegeneration.
Ximaine R. van der Burg, Danielle V. Toen, Scott Ayton, Hanno Pijl, Louise van der Weerd   +4 more
wiley   +1 more source

GmRPS5 Promoter‐Driven CRISPR/LbCas12a Efficiently Generates Soybean Sextuple Mutants

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3494-3496, May 2026.
Xiangchao Kong, Kexin Fan, Cuiping Xin, Minhui Lu, Yunlu Shi, Jie Jin, Qi‐Jun Chen   +6 more
wiley   +1 more source