Avenanthramides as lipoxygenase inhibitors [PDF]
Heliyon, 2020 Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties.
Rikard Landberg +2 more
doaj +7 more sources
5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. [PDF]
PLoS ONE, 2014 The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis.
Han-Ching Lin +9 more
doaj +4 more sources
Bioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors [PDF]
Biology, 2023 Lipoxygenases are non-heme iron-containing enzymes that catalyze the oxidation of polyunsaturated fatty acids, resulting in the production of lipid hydroperoxides, which are precursors of inflammatory lipid mediators. These enzymes are widely distributed
Fai-Chu Wong, Tsun-Thai Chai
doaj +2 more sources
Lipoxygenase inhibitors derived from marine macroalgae [PDF]
Bioorganic & Medicinal Chemistry Letters, 2014 The solvent extracts from the algae Sargassum thunbergii (Sargassaceae) and Odonthalia corymbifera (Rhodomelaceae) were subjected to soybean lipoxygenase inhibitory screening. Two hydrophobic inhibitors were obtained from the extracts of S. thunbergii through inhibitory assay-guided fractionation.
Kurihara, Hideyuki +4 more
openaire +4 more sources
Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers has
Hamid Sadeghian +2 more
doaj +2 more sources
α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells [PDF]
Marine Drugs, 2021 Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic acid cascade are involved in oncogenesis.
Tatiana I. Terpinskaya +10 more
doaj +2 more sources
A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. [PDF]
Anal Biochem, 2015 Lipoxygenases (LOXs) regulate inflammation through the production of a variety of molecules whose specific downstream effects are not entirely understood due to the complexity of the inflammation pathway.
Jameson JB, Kenyon V, Holman TR.
europepmc +3 more sources
α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors [PDF]
Marine Drugs, 2020 Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a
Alexey V. Osipov +6 more
doaj +2 more sources
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes. [PDF]
PLoS ONE, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
Thea K Wöbke +3 more
doaj +4 more sources
Microwave Assisted Synthesis of Antioxidant Dihydro-Pyrazole Hybrids as Possible Lipoxygenase Inhibitors [PDF]
MoleculesFree radicals and inflammation have pivotal role in various degenerative diseases like cancer, rheumatoid arthritis, diabetes, cardiovascular and neurodegenerative disorders.
Stergiani-Chrysovalanti Peitzika +2 more
doaj +2 more sources