Results 1 to 10 of about 43,549 (263)

Synthesis and Molecular Modeling of Antioxidant and Anti-Inflammatory Five-Membered Heterocycle–Cinnamic Acid Hybrids [PDF]

Molecules
In this study, the design and synthesis of a novel series of cinnamic acid and 1,2,4-triazole hybrids were reported, aiming to enhance antioxidant and lipoxygenase inhibitory activities through pharmacophore combination. Cinnamic acid derivatives and 1,2,
Konstantinos Theodoridis, Eleftherios Charissopoulos, Dimitra Tsioumela, Eleni Pontiki   +3 more
doaj   +2 more sources

The Inhibition of 15-Lipoxygenase by Blechnum orientale Leaves and its Glycoside-flavonoid Isolates: In Vitro and In Silico Studies

Hayati Journal of Biosciences, 2022
Fern is one of the groups of primitive plants rich in secondary metabolites that are commonly used to treat various diseases, including antioxidant, anti-hyaluronidase, anti-inflammation, and respiratory disease but less investigated.
Rissyelly Rissyelly, Syaikhul Aziz, Frangky Sangande, Agung Wibawa Mahatva Yodha, Krisyanti Budipramana, Elfahmi Elfahmi, Sukrasno Sukrasno   +6 more
doaj   +1 more source

Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?

Molecules, 2023
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered ...
Alexander Zhuravlev, Alejandro Cruz, Vladislav Aksenov, Alexey Golovanov, José M. Lluch, Hartmut Kuhn, Àngels González-Lafont, Igor Ivanov   +7 more
doaj   +1 more source

A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus [PDF]

PeerJ, 2023
Arachidonic acid 15-lipoxygenase (ALOX15), as one of the lipoxygenase family, is mainly responsible for catalyzing the oxidation of various fatty acids to produce a variety of lipid components, contributing to the pathophysiological processes of various ...
Kaiying He, Xiaochun Zhou, Hongxuan Du, Jing Zhao, Rongrong Deng, Jianqin Wang   +5 more
doaj   +2 more sources

Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils

Cells, 2021
The endocannabinoids 2-arachidonoyl-glycerol and N-arachidonoyl-ethanolamine are lipids regulating many physiological processes, notably inflammation. Endocannabinoid hydrolysis inhibitors are now being investigated as potential anti-inflammatory agents.
Anne-Sophie Archambault, Francesco Tinto, Élizabeth Dumais, Volatiana Rakotoarivelo, Magdalena Kostrzewa, Pier-Luc Plante, Cyril Martin, Mélissa Simard, Cristoforo Silvestri, Roxane Pouliot, Michel Laviolette, Louis-Philippe Boulet, Rosa Maria Vitale, Alessia Ligresti, Vincenzo Di Marzo, Nicolas Flamand   +15 more
doaj   +1 more source

α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells

Marine Drugs, 2021
Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic acid cascade are involved in oncogenesis.
Tatiana I. Terpinskaya, Alexey V. Osipov, Elena V. Kryukova, Denis S. Kudryavtsev, Nina V. Kopylova, Tatsiana L. Yanchanka, Alena F. Palukoshka, Elena A. Gondarenko, Maxim N. Zhmak, Victor I. Tsetlin, Yuri N. Utkin   +10 more
doaj   +1 more source

Novel lipoxygenase inhibitors as neuroprotective reagents [PDF]

Journal of Neuroscience Research, 2007
AbstractThe lipid‐metabolizing enzyme 12/15‐lipoxygenase (12/15‐LOX) mediates cell death resulting from oxidative stress in both neurons and oligodendrocytes. Specifically, it may contribute to the pathophysiology of stroke and Alzheimer's and Parkinson's diseases.
van Leyen, Klaus, Arai, Ken, Jin, Guang, Kenyon, Victor, Gerstner, Bettina, Rosenberg, Paul A, Holman, Theodore R, Lo, Eng H   +7 more
openaire   +4 more sources

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. [PDF]

, 2009
Pharmacological suppression of leukotriene biosynthesis by inhibitors of 5-lipoxygenase (5-LO) is a strategy to intervene with inflammatory and allergic disorders.
BÜHRING U, KARG EM, LUDERER S, NORTHOFF H, PERGOLA C, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, TROSCHÜTZ R, WERZ O.   +8 more
core   +1 more source

Lipoxygenase inhibitors derived from marine macroalgae [PDF]

Bioorganic & Medicinal Chemistry Letters, 2014
The solvent extracts from the algae Sargassum thunbergii (Sargassaceae) and Odonthalia corymbifera (Rhodomelaceae) were subjected to soybean lipoxygenase inhibitory screening. Two hydrophobic inhibitors were obtained from the extracts of S. thunbergii through inhibitory assay-guided fractionation.
Kurihara, Hideyuki, Kagawa, Yoshio, Konno, Remi, Kim, Sang Moo, Takahashi, Koretaro   +4 more
openaire   +3 more sources

Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.

PLoS ONE, 2010
TRPM7 is a ubiquitous divalent-selective ion channel with its own kinase domain. Recent studies have shown that suppression of TRPM7 protein expression by RNA interference increases resistance to ischemia-induced neuronal cell death in vivo and in vitro,
Hsiang-Chin Chen, Jia Xie, Zheng Zhang, Li-Ting Su, Lixia Yue, Loren W Runnels   +5 more
doaj   +1 more source