Results 151 to 160 of about 23,162 (241)
ABSTRACT Type 2 diabetes mellitus (T2DM) is a central component of the metabolic syndrome (MetS) and is associated with underlying mitochondrial dysfunction. Disruption of mitochondrial homeostasis impairs cellular energy metabolism and contributes to the overproduction of reactive oxygen species (ROS), leading to oxidative stress, chronic inflammation,
Shanika Reddy +3 more
wiley +1 more source
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source
A Multistep Computational Approach to Achieve a Complete Human 5-Lipoxygenase Structure and Provide a Pharmacophore Model for Further Drug Design. [PDF]
Lombardo L +3 more
europepmc +1 more source
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
Red Grape Pomace as a Valuable Source of Biomolecules With Inhibitory Effect on Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes: Eco-Friendly Extraction and Mechanism of Inhibition. [PDF]
Balan N +6 more
europepmc +1 more source
Selection of Wheat Germ Drying Methods Using Multi‐Criteria Decision‐Making Techniques
The parameters for the analysis of dried wheat germ were weighted using the MEREC method, with the most critical criterion being antioxidant capacity. The COBRA method was employed to evaluate a total of 15 alternatives. The most effective drying method for wheat germ was determined to be the combination of vacuum pre‐drying and microwave finish‐drying
Aliye Ayca Supciller +2 more
wiley +1 more source
Orchid genome evolution and trait innovation
Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng +8 more
wiley +1 more source
ERF transcription factor StPti5 is a regulator of endophyte community maintenance in potato
Summary We have recently identified an ethylene response factor, StPti5, as a susceptibility factor that negatively regulates immune responses to diverse pathogens. Here, we investigated the role of StPti5 in the processes involved in the colonization of potato with beneficial organisms.
Tjaša Lukan +18 more
wiley +1 more source
ABSTRACT Rice is the staple crop for more than half of the global population, and improving grain yield, grain quality, and stress resistance remain central goals of modern rice breeding. Among current precision breeding strategies, genome editing has created new opportunities for crop improvement, but its success depends heavily on the selection of ...
Wenhao Wu +4 more
wiley +1 more source
Allosteric properties of mammalian ALOX15 orthologs. [PDF]
Yang J, Borchert A, Kuhn H.
europepmc +1 more source

