Results 181 to 190 of about 23,162 (241)
<i>Khaya grandifololia</i> exerts multitarget neuroprotective potential against neurodegenerative disorders: <i>In vitro</i> and <i>in silico</i> studies. [PDF]
IBRO Neurosci RepElla FA +3 more
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Lipoxygenase inhibitors for the treatment of pancreatic cancer
Expert Review of Anticancer Therapy, 2003Pancreatic cancer has a dismal prognosis with no effective medical therapy. Therefore, there is a need to search for novel targets for cancer prevention and treatment. The lipoxygenases oxygenate arachidonic acid and other 20-carbon fatty acids and their downstream metabolites have been found to mediate several aspects of pancreatic cancer development ...
Thomas Adrian +2 more
exaly +3 more sources
Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Naglaa Ahmed, Heba Taha, Sahar Ali
exaly +2 more sources
Silymarin, an inhibitor of lipoxygenase
Experientia, 1979Silybin (I), silydianin (II) and silychristin (III), the constituents of silymarin, non-competitively inhibit the lipoxygenase from soybeans (EC 1.13.11.12) in vitro.
F, Fiebrich, H, Koch
openaire +2 more sources
Anthocyanins as lipoxygenase inhibitors
Molecular Nutrition & Food Research, 2009AbstractHealth benefits associated with diets rich in anthocyanins are ascribed to multilevel biological activities including antioxidative and anti‐inflammatory effects. The present study addresses lipoxygenase inhibition as a mechanism by which anthocyanins may exert health promoting effects. The inhibitory potential of delphinidin (Dp), cyanidin (Cy)
Bastian, Knaup +3 more
openaire +2 more sources
Review: lipoxygenase inhibitors and the gut
Alimentary Pharmacology & Therapeutics, 1987SUMMARYLeukotriene synthesis is influenced by several drugs currently in use for the treatment of alimentary disease, including the corticosteroids, sulphasalazine and mesalazine. However, the use of selective lipoxygenase inhibitors in human gastrointestinal disease has not been investigated. The complexity of eicosanoid metabolism, and the incomplete
N P, Kennedy, P W, Keeling
openaire +2 more sources
Episulfide inhibitors of lipoxygenase
Bioorganic & Medicinal Chemistry Letters, 1992Abstract A set of epoxide and episulfide substrate mimics were synthesized as inhibitors of soybean lipoxygenase. Enzyme inhibition was observed exclusively with the 12,13-episulfides (1a and 4a), with a high degree of regio- and chemoselectivity. Inhibition by 1a was shown to occur with reduction of the enzyme active site iron from the catalytically
Stephen W. Wright, Mark J. Nelson
openaire +1 more source
15-Lipoxygenase inhibitors: a patent review
Expert Opinion on Therapeutic Patents, 201515-Lipoxygenases (15-LOXes) are a family of iron-containing proteins that have the capability for unsaturated fatty acid peroxidation in animals and plants. Two types of the enzyme, 15-LOX-1 and 15-LOX-2, have been recognized in mammals to have different abilities in the peroxidation of arachidonic acid and linoleic acid.
Hamid, Sadeghian, Atena, Jabbari
openaire +2 more sources
Hydroxamic acid inhibitors of 5-lipoxygenase
Journal of Medicinal Chemistry, 1987The hydroxamic acid functionality can be incorporated in a variety of simple molecules to produce potent inhibitors of 5-lipoxygenase. As an example of this, the structure-activity relationships in a series of omega-phenylalkyl and omega-naphthylalkyl hydroxamic acids are presented. Among the features described are the influence of hydrophobicity, aryl
J B, Summers +5 more
openaire +2 more sources
4-Hydroxythiazole inhibitors of 5-lipoxygenase
Journal of Medicinal Chemistry, 19914-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 microM. An investigation of structure-activity relationships showed that the most potent inhibitors of this series are the 5-phenyl derivatives. The corresponding thiazolidin-4-one analogues were found to be relatively inactive.
F A, Kerdesky +6 more
openaire +2 more sources