Results 191 to 200 of about 23,162 (241)
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[Inhibitors of 5-lipoxygenase].
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2002Leukotrienes are powerful mediators of inflammation processes. Possibilities of their biosynthesis inhibition have been intensively studied during recent two decades aiming to develop new methods of therapy of various inflammatory diseases, particularly asthma. Biosynthesis of all leukotrienes is dependent on the production of the key intermediate LTA4.
M, Gápovský, M, Remko
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Evaluation of the antioxidative properties of lipoxygenase inhibitors
Pharmacological Reports, 2012Oxidative stress is a component of many pathological conditions including neurodegenerative diseases and inflammation. An important source of reactive oxygen species (ROS) are lipoxygenases (LOX) - enzymes responsible for the metabolism of arachidonic acid and other polyunsaturated fatty acids.
Grzegorz A, Czapski +2 more
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5-Lipoxygenase Inhibitors for the Treatment of COPD
Chest, 2002The potential for leukotrienes as mediators to target in the development of novel therapies for diseases such as COPD is underscored by their inflammatory behavior and the capacity of leukotriene receptor antagonists and synthesis inhibitors to reduce inflammatory responses when administered in vivo.
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Endogenous inhibitors of lipoxygenase
European Journal of Pharmacology, 1980S A, Saeed, M, Drew, H O, Collier
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Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis
Current Pharmaceutical Design, 2009The inflammatory environment within the atherosclerotic lesion stimulates the 5-lipoxygenase pathway of arachidonic acid metabolism, leading to the biosynthesis of the potent lipid inflammatory mediators leukotrienes. The present review summarizes the components of this pathway; the enzymes 5-lipoxygenase (5-LO, ALOX5) with its activating protein, FLAP
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Natural Inhibitors against Potential Targets of Cyclooxygenase, Lipoxygenase and Leukotrienes
Combinatorial Chemistry and High Throughput Screening, 2022Anil Saxena +2 more
exaly
Inhibitors of Cyclooxygenase and 5-Lipoxygenase
Current Medicinal Chemistry, 1994Donald T Witiak
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Lipoxygenase Inhibitors Prevent Lung Carcinogenesis and Inhibit Non-Small Cell Lung Cancer Growth
Experimental Lung Research, 1998Terry Moody +2 more
exaly