Results 211 to 220 of about 25,002 (268)

Shichangpu-Xiyangshen Herb Extract Alleviates Cognitive Dysfunction in Type 1 Diabetes Through Metabolism of Arachidonic Acid Cyclooxygenase and Lipoxygenase. [PDF]

Molecules
Wang J, Wang D, Yang Y, Jing C, Li X, Xin Y, Wang Y, Xie H.   +7 more
europepmc   +1 more source

Advances in Beyond Statin Lipid Therapies for ASCVD Risk Reduction. [PDF]

J Atheroscler Thromb
Shimabukuro M.
europepmc   +1 more source

Causal demonstration of adiposity-induced adipose-specific signaling derangements in the pathogenesis of the clinical features of the cardiovascular-kidney metabolic syndrome. [PDF]

Cardiovasc Diabetol
Packer M.
europepmc   +1 more source

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Lipoxygenase inhibitors for the treatment of pancreatic cancer

Expert Review of Anticancer Therapy, 2003
Pancreatic cancer has a dismal prognosis with no effective medical therapy. Therefore, there is a need to search for novel targets for cancer prevention and treatment. The lipoxygenases oxygenate arachidonic acid and other 20-carbon fatty acids and their downstream metabolites have been found to mediate several aspects of pancreatic cancer development ...
Xian-Zhong Ding, T E Adrian
exaly   +3 more sources

Inhibitors of Cyclooxygenase and 5-Lipoxygenase

Current Medicinal Chemistry, 1994
Abstract: Prostaglandin H synthase (PGH synthase) and 5-Lipoxygenase (5-LO) are important enzymes that catalyze the formation of putative intermediates involved in the inflammatory process. The mechanism by which PGH synthase and 5-LO convert their common substrate arachidonic acid (AA) into prostaglandins, thromboxanes and leukotrienes is discussed ...
Donald T Witiak
exaly   +2 more sources

Silymarin, an inhibitor of lipoxygenase

Experientia, 1979
Silybin (I), silydianin (II) and silychristin (III), the constituents of silymarin, non-competitively inhibit the lipoxygenase from soybeans (EC 1.13.11.12) in vitro.
F, Fiebrich, H, Koch
openaire   +2 more sources

Anthocyanins as lipoxygenase inhibitors

Molecular Nutrition & Food Research, 2009
AbstractHealth benefits associated with diets rich in anthocyanins are ascribed to multilevel biological activities including antioxidative and anti‐inflammatory effects. The present study addresses lipoxygenase inhibition as a mechanism by which anthocyanins may exert health promoting effects. The inhibitory potential of delphinidin (Dp), cyanidin (Cy)
Bastian, Knaup, Anett, Oehme, Anagnostis, Valotis, Peter, Schreier   +3 more
openaire   +2 more sources

Review: lipoxygenase inhibitors and the gut

Alimentary Pharmacology & Therapeutics, 1987
SUMMARYLeukotriene synthesis is influenced by several drugs currently in use for the treatment of alimentary disease, including the corticosteroids, sulphasalazine and mesalazine. However, the use of selective lipoxygenase inhibitors in human gastrointestinal disease has not been investigated. The complexity of eicosanoid metabolism, and the incomplete
N P, Kennedy, P W, Keeling
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Episulfide inhibitors of lipoxygenase

Bioorganic & Medicinal Chemistry Letters, 1992
Abstract A set of epoxide and episulfide substrate mimics were synthesized as inhibitors of soybean lipoxygenase. Enzyme inhibition was observed exclusively with the 12,13-episulfides (1a and 4a), with a high degree of regio- and chemoselectivity. Inhibition by 1a was shown to occur with reduction of the enzyme active site iron from the catalytically
Stephen W. Wright, Mark J. Nelson
openaire   +1 more source