Results 11 to 20 of about 4,273 (194)

Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana [PDF]

Metabolites, 2019
Plant de novo fatty acid synthesis takes place in the plastid using acetyl-coenzyme A (acetyl-CoA) as the main precursor. This first intermediate is produced from pyruvate through the action of the plastidial pyruvate dehydrogenase complex (PDH), which ...
Raquel Martins-Noguerol, Antonio Javier Moreno-Pérez, Sebastien Acket, Salim Makni, Rafael Garcés, Adrián Troncoso-Ponce, Joaquín J. Salas, Brigitte Thomasset, Enrique Martínez-Force   +8 more
doaj   +5 more sources

Multifunctional H2S‐activated metal‐organic framework systems for targeted colorectal cancer imaging and synergistic copper‐induced tumor regression

BMEMat
Stimuli‐responsive nanomaterials offer significant potential for enhancing diagnostic accuracy, optimizing therapeutic efficacy, and advancing precision theranostics.
Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu   +13 more
doaj   +2 more sources

Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS [PDF]

Redox Biology
Renal ischemia-reperfusion injury (RIRI), a major contributor to acute kidney injury (AKI) and delayed graft function (DGF), is closely associated with dysregulation of metal ion homeostasis.
Siyue Chen, Tingting Chen, Cuidi Xu, Xiaohan Yu, Junyu Shi, Cheng Yang, Tongyu Zhu   +6 more
doaj   +2 more sources

A Deep Clinical and Biochemical Characterization of a Patient With Combined Malonic and Methylmalonic Aciduria (CMAMMA). [PDF]

JIMD Rep
ABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA) is an inborn error of metabolism caused by a deficiency in mitochondrial malonyl‐CoA synthetase, the enzyme responsible for activating malonic acid (MA) to malonyl‐CoA, a precursor of lipoic acid.
Gragnaniello V, Galderisi A, Tucci S, Doimo M, Caterino M, Loro C, Cazzorla C, Ruoppolo M, Salviati L, Burlina AB.   +9 more
europepmc   +2 more sources

Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea. [PDF]

PLoS ONE, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic environmental interactions?
Kirill Borziak, Mareike G Posner, Abhishek Upadhyay, Michael J Danson, Stefan Bagby, Steve Dorus   +5 more
doaj   +1 more source

Genetic dissection of the mitochondrial lipoylation pathway in yeast

BMC Biology, 2021
Background Lipoylation of 2-ketoacid dehydrogenases is essential for mitochondrial function in eukaryotes. While the basic principles of the lipoylation processes have been worked out, we still lack a thorough understanding of the details of this ...
Laura P. Pietikäinen, M. Tanvir Rahman, J. Kalervo Hiltunen, Carol L. Dieckmann, Alexander J. Kastaniotis   +4 more
doaj   +1 more source

Lipoylating and biotinylating enzymes contain a homologous catalytic module [PDF]

Protein Science, 2000
Biotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions.
Reche Gallardo, Pedro Antonio
core   +7 more sources

Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma

Frontiers in Medicine, 2022
Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu, Hanwen Lu, Liwei Zhou, Liwei Zhou, Bingchang Zhang, Bingchang Zhang, Yuanyuan Xie, Yuanyuan Xie, Huiyin Yang, Huiyin Yang, Zhanxiang Wang, Zhanxiang Wang, Zhanxiang Wang   +12 more
doaj   +1 more source

Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System

Frontiers in Genetics, 2021
Glycine cleavage system H protein (GCSH) is a component of the glycine cleavage system (GCS), a conserved protein complex that acts to decarboxylate glycine.
Kit-Yi Leung, Sandra C. P. De Castro, Gabriel L. Galea, Andrew J. Copp, Nicholas D. E. Greene   +4 more
doaj   +1 more source

Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency. [PDF]

J Biol Chem
Protein lipoylation, a vital lysine post-translational modification, plays a crucial role in the function of key mitochondrial tricarboxylic acid cycle enzymatic complexes. In eukaryotes, lipoyl post-translational modification synthesis occurs exclusively through de novo pathways, relying on lipoyl synthesis/transfer enzymes, dependent upon ...
Bick NR, Dreishpoon MB, Perry A, Rogachevskaya A, Bottomley SS, Fleming MD, Ducamp S, Tsvetkov P.   +7 more
europepmc   +3 more sources