Ferredoxins: master regulators in mitochondrial redox homeostasis and programmed cell death [PDF]
Redox BiologyFerredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe–S) proteins that serve as master regulators of mitochondrial redox homeostasis, governing critical processes including electron transfer, energy metabolism, Fe–S cluster biogenesis, and ...
Yajuan Lu +13 more
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Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS [PDF]
Redox BiologyRenal ischemia-reperfusion injury (RIRI), a major contributor to acute kidney injury (AKI) and delayed graft function (DGF), is closely associated with dysregulation of metal ion homeostasis.
Siyue Chen +6 more
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Chemoselective and laser cleavable probes for <i>in situ</i> protein lipoylation detection by laser desorption/ionization mass spectrometry. [PDF]
Chem SciDu Q +8 more
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Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in
mBio, 2018 Lipoate is a redox active cofactor that is covalently bound to key enzymes of oxidative metabolism. Plasmodium falciparum is auxotrophic for lipoate during the intraerythrocytic stages, but it is not known whether lipoate attachment to protein is ...
Hugo Jhun +2 more
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Evidence for two protein‐lipoylation activities in Escherichia coli [PDF]
FEBS Letters, 1991 The lipoate acyltransferase subunits of the 2‐oxo acid dehydrogenase complexes are post‐translationally modified with one or more covalently‐bound lipoyl cofactors. Two distinct lipoate‐protein ligase activities, LPL‐A and LPL‐B, have been detected in E. coli by their ability to modify purified lipoyl apo‐domains of the bacterial pyruvate dehydrogenase
Dawn E. Brookfield +4 more
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Impairment of lipoylation mediated by bromooctanoate targets eukaryotic amidotransferases [PDF]
Molecular MicrobiologyABSTRACTLipoylation is a post‐translational modification in which lipoic acid is attached to specific apoproteins of enzyme complexes, like E2 subunits of dehydrogenases or GcvH of the glycine cleavage system. A defining feature of organisms with a lipoyl‐relay system is the presence of amidotransferase activity, which enables the transfer of lipoyl ...
Albertina Scattolini +4 more
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A Deep Clinical and Biochemical Characterization of a Patient With Combined Malonic and Methylmalonic Aciduria (CMAMMA). [PDF]
JIMD RepABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA) is an inborn error of metabolism caused by a deficiency in mitochondrial malonyl‐CoA synthetase, the enzyme responsible for activating malonic acid (MA) to malonyl‐CoA, a precursor of lipoic acid.
Gragnaniello V +9 more
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Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism. [PDF]
Nat Cell BiolKim D +20 more
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Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis [PDF]
Communications BiologyCuproptosis, a copper-triggered cell death pathway, holds therapeutic potential for cancers, but its regulatory mechanisms in hepatocellular carcinoma (HCC) remain undefined.
Chutian Wu +10 more
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