Results 11 to 20 of about 4,213 (194)

Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency. [PDF]

J Biol Chem
Protein lipoylation, a vital lysine post-translational modification, plays a crucial role in the function of key mitochondrial tricarboxylic acid cycle enzymatic complexes. In eukaryotes, lipoyl post-translational modification synthesis occurs exclusively through de novo pathways, relying on lipoyl synthesis/transfer enzymes, dependent upon ...
Bick NR, Dreishpoon MB, Perry A, Rogachevskaya A, Bottomley SS, Fleming MD, Ducamp S, Tsvetkov P.   +7 more
europepmc   +5 more sources

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Kazuki Tajima, Kenji Ikeda, Hsin‐Yi Chang, Chih‐Hsiang Chang, Takeshi Yoneshiro, Yasuo Oguri, Heejin Jun, Jun Wu, Yasushi Ishihama, Shingo Kajimura   +9 more
openalex   +4 more sources

A Deep Clinical and Biochemical Characterization of a Patient With Combined Malonic and Methylmalonic Aciduria (CMAMMA). [PDF]

JIMD Rep
ABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA) is an inborn error of metabolism caused by a deficiency in mitochondrial malonyl‐CoA synthetase, the enzyme responsible for activating malonic acid (MA) to malonyl‐CoA, a precursor of lipoic acid.
Gragnaniello V, Galderisi A, Tucci S, Doimo M, Caterino M, Loro C, Cazzorla C, Ruoppolo M, Salviati L, Burlina AB.   +9 more
europepmc   +2 more sources

Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast-Like Synoviocyte. [PDF]

Int J Rheum Dis
ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic synovitis and skeletal joint deformities, often accompanied by systemic symptoms. Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids ...
Zhi X, Zhu H, Sun X, Wang Z, Wang L, Song G.   +5 more
europepmc   +2 more sources

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis. [PDF]

Nat Commun
Hsiao JC, Warui DM, Kwon JJ, Dreishpoon MB, Bick NR, Blue-Lahom T, Root DE, Booker SJ, Tsvetkov P.   +8 more
europepmc   +4 more sources

Compromised Mitochondrial Fatty Acid Synthesis in Transgenic Mice Results in Defective Protein Lipoylation and Energy Disequilibrium [PDF]

, 2012
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health.
S. G. Smith, Andrzej Witkowski, Ayesha Moghul, Yuko Yoshinaga, Michael Nefedov, Peter J. de Jong, Dejiang Feng, Loren G. Fong, Yiping Tu, Yan Hu, Stephen G. Young, Thomas Pham, Carling Cheung, Shana M. Katzman, Martin D. Brand, Casey L. Quinlan, Marcel H.A.M. Fens, Frans A. Kuypers, Stephanie A. Misquitta, Stephen M. Griffey, Son N. Tran, Afshin Gharib, Jens Knudsen, Hans Kristian Hannibal‐Bach, Grace Wang, Sandra Larkin, Jennifer L. Thweatt, Saloni Pasta   +27 more
openalex   +7 more sources

Tumor glucose reprogramming suppresses cuproptosis: A review. [PDF]

Biomol Biomed
Cuproptosis is a copper-dependent form of regulated cell death that begins when ferredoxin 1 (FDX1) reduces Cu²⁺ to Cu¹⁺, allowing the ion to bind lipoylated enzymes of the tricarboxylic-acid (TCA) cycle, drive protein aggregation, dismantle iron–sulphur
Song XH, Ding YH, Chen JS.
europepmc   +3 more sources

A unique lipoylation system in the Archaea [PDF]

The FEBS Journal, 2009
Members of the 2-oxoacid dehydrogenase multienzyme complex family play a key role in the pathways of central metabolism. Post-translational lipoylation of the dihydrolipoyl acyltransferase component of these complexes is essential for their activity, the lipoyllysine moiety performing the transfer of substrates and intermediates between the different ...
Mareike G. Posner, Abhishek Upadhyay, Stefan Bagby, David W. Hough, Michael J. Danson   +4 more
openalex   +4 more sources

Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein. [PDF]

Nat Commun
Yang R, Wang Y, Kong M, Hu Z, Zhang Z, Shen K, Meng J, Zeng AP.   +7 more
europepmc   +3 more sources

Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential. [PDF]

Cell Death Discov
Li S, Liu Y, Hu W, Deng A, Ren X, Chen L, Lu Y, Wu Y, Huang H, Cao J, Du J, Xia J, Li Y.   +12 more
europepmc   +3 more sources