Results 21 to 30 of about 3,490 (194)

Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma

Frontiers in Medicine, 2022
Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu, Hanwen Lu, Liwei Zhou, Liwei Zhou, Bingchang Zhang, Bingchang Zhang, Yuanyuan Xie, Yuanyuan Xie, Huiyin Yang, Huiyin Yang, Zhanxiang Wang, Zhanxiang Wang, Zhanxiang Wang   +12 more
doaj   +1 more source

Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea. [PDF]

PLoS ONE, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic environmental interactions?
Kirill Borziak, Mareike G Posner, Abhishek Upadhyay, Michael J Danson, Stefan Bagby, Steve Dorus   +5 more
doaj   +1 more source

Genetic dissection of the mitochondrial lipoylation pathway in yeast

BMC Biology, 2021
Background Lipoylation of 2-ketoacid dehydrogenases is essential for mitochondrial function in eukaryotes. While the basic principles of the lipoylation processes have been worked out, we still lack a thorough understanding of the details of this ...
Laura P. Pietikäinen, M. Tanvir Rahman, J. Kalervo Hiltunen, Carol L. Dieckmann, Alexander J. Kastaniotis   +4 more
doaj   +1 more source

Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System

Frontiers in Genetics, 2021
Glycine cleavage system H protein (GCSH) is a component of the glycine cleavage system (GCS), a conserved protein complex that acts to decarboxylate glycine.
Kit-Yi Leung, Sandra C. P. De Castro, Gabriel L. Galea, Andrew J. Copp, Nicholas D. E. Greene   +4 more
doaj   +1 more source

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair. [PDF]

Sci Adv
Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, Timmerman RD, DeBerardinis RJ, Zhang Y.   +12 more
europepmc   +2 more sources

An Essential Role of Mitochondrial α-Ketoglutarate Dehydrogenase E2 in the Basal Immune Response Against Bacterial Pathogens in Tomato

Frontiers in Plant Science, 2020
Plants intensely modulate respiration when pathogens attack, but the function of mitochondrial respiration-related genes in plant–bacteria interaction is largely unclear.
Qiaomei Ma, Yaru Liu, Hanmo Fang, Ping Wang, Golam Jalal Ahammed, Wenshan Zai, Kai Shi   +6 more
doaj   +1 more source

Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. [PDF]

PLoS ONE, 2012
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health.
Stuart Smith, Andrzej Witkowski, Ayesha Moghul, Yuko Yoshinaga, Michael Nefedov, Pieter de Jong, Dejiang Feng, Loren Fong, Yiping Tu, Yan Hu, Stephen G Young, Thomas Pham, Carling Cheung, Shana M Katzman, Martin D Brand, Casey L Quinlan, Marcel Fens, Frans Kuypers, Stephanie Misquitta, Stephen M Griffey, Son Tran, Afshin Gharib, Jens Knudsen, Hans Kristian Hannibal-Bach, Grace Wang, Sandra Larkin, Jennifer Thweatt, Saloni Pasta   +27 more
doaj   +1 more source

FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis

Heliyon, 2023
Cuprotosis is a recently identified cell death form that caused by intracellular copper accumulation and regulated by FDX1. This work aimed to explore the role of cuprotosis and the pivotal regulatory gene FDX1 in thyroid cancer development.
Gaoxiang Chen, Jianan Zhang, Weifeng Teng, Yong Luo, Xiaochun Ji   +4 more
doaj   +1 more source

Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast-Like Synoviocyte. [PDF]

Int J Rheum Dis
ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic synovitis and skeletal joint deformities, often accompanied by systemic symptoms. Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids ...
Zhi X, Zhu H, Sun X, Wang Z, Wang L, Song G.   +5 more
europepmc   +2 more sources

Lipoamidase (lipoyl-X hydrolase) from pig brain [PDF]

Biochemical Journal, 1990
Although the optimum substrate for lipoamidase (lipoyl-X hydrolase) has not yet been determined, it is known that lipoamidase activity, as determined by hydrolysis of the synthetic substrate lipoyl 4-aminobenzoate (LPAB), is widely distributed in pig brain tissues, i.e. in the cerebrum, cerebellum and medulla. Over 95% of the enzyme activity is present
J, Oizumi, K, Hayakawa
openaire   +2 more sources