Lipoylation Mechanism of P. Falciparum Mitochondrial Proteins [PDF]
Biophysical Journal, 2015 Lipoate is an essential cofactor for the aerobic metabolism in oxidative decarboxylation reactions of 2-oxoacid complexes. Malaria parasite survival is highly dependent on scavenging this essential cofactor from the human host. Scavenged lipoate is subsequently attached to the α-ketoglutarate dehydrogenase (KDH), the branched chain α-ketoacid ...
Alfredo J. Guerra +3 more
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Knockout studies reveal an important role of plasmodium lipoic acid protein ligase a1 for asexual blood stage parasite survival [PDF]
, 2009 Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of a-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation.
A Witkowski +37 more
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Chemoselective and laser cleavable probes for <i>in situ</i> protein lipoylation detection by laser desorption/ionization mass spectrometry. [PDF]
Chem SciDu Q +8 more
europepmc +3 more sources
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex [PDF]
Bailey PSJ +8 more
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Novel insights into the Thaumarchaeota in the deepest oceans: their metabolism and potential adaptation mechanisms [PDF]
, 2020 Background: Marine Group I (MGI) Thaumarchaeota, which play key roles in the global biogeochemical cycling of nitrogen and carbon (ammonia oxidizers), thrive in the aphotic deep sea with massive populations.
Lehtovirta-Morley, Laura +8 more
core +2 more sources
Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus [PDF]
, 2021 Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very ...
Du, Xiaochen +4 more
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Overexpressing the H-protein of the glycine cleavage system increases biomass yield in glasshouse and field grown transgenic tobacco plants [PDF]
, 2018 Photorespiration is essential for C3 plants, enabling oxygenic photosynthesis through the scavenging of 2‐phosphoglycolate. Previous studies have demonstrated that overexpression of the L‐ and H‐proteins of the photorespiratory glycine cleavage system ...
Brown, Kenny L +5 more
core +2 more sources
Lipoamidase (lipoyl-X hydrolase) from pig brain [PDF]
Biochemical Journal, 1990 Although the optimum substrate for lipoamidase (lipoyl-X hydrolase) has not yet been determined, it is known that lipoamidase activity, as determined by hydrolysis of the synthetic substrate lipoyl 4-aminobenzoate (LPAB), is widely distributed in pig brain tissues, i.e. in the cerebrum, cerebellum and medulla. Over 95% of the enzyme activity is present
J, Oizumi, K, Hayakawa
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Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components [PDF]
, 2015 Individual recombinant components of pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes (PDHc, OGDHc) of human and Escherichia coli (E. coli) origin were expressed and purified from E. coli with optimized protocols.
Adam-Vizi +123 more
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Lipoyl-E2-PDH Gets a Second Job [PDF]
Cell Host & Microbe, 2017 Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress TLR-mediated activation of host macrophages by bacterial lipoproteins.
Seth W, Dickey, Michael, Otto
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