Boosting Cuproptosis in Breast Cancer Therapy via Photodynamic Treatment With a New Liposome. [PDF]
FASEB BioadvABSTRACT Breast cancer (BC) is one of the most common cancers in women around the world, and utilizing a combined approach is a crucial strategy. Induction of cuproptosis in tumor cells is a novel antitumor approach, though its standalone efficacy remains unclear.
Yu J +9 more
europepmc +2 more sources
Novel insights into the Thaumarchaeota in the deepest oceans: their metabolism and potential adaptation mechanisms [PDF]
, 2020 Background: Marine Group I (MGI) Thaumarchaeota, which play key roles in the global biogeochemical cycling of nitrogen and carbon (ammonia oxidizers), thrive in the aphotic deep sea with massive populations.
Lehtovirta-Morley, Laura +8 more
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FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis
Heliyon, 2023 Cuprotosis is a recently identified cell death form that caused by intracellular copper accumulation and regulated by FDX1. This work aimed to explore the role of cuprotosis and the pivotal regulatory gene FDX1 in thyroid cancer development.
Gaoxiang Chen +4 more
doaj +1 more source
A unique lipoylation system in the Archaea [PDF]
The FEBS Journal, 2009 Members of the 2-oxoacid dehydrogenase multienzyme complex family play a key role in the pathways of central metabolism. Post-translational lipoylation of the dihydrolipoyl acyltransferase component of these complexes is essential for their activity, the lipoyllysine moiety performing the transfer of substrates and intermediates between the different ...
Mareike G, Posner +4 more
openaire +2 more sources
Frontiers in Plant Science, 2020 Plants intensely modulate respiration when pathogens attack, but the function of mitochondrial respiration-related genes in plant–bacteria interaction is largely unclear.
Qiaomei Ma +6 more
doaj +1 more source
Overexpressing the H-protein of the glycine cleavage system increases biomass yield in glasshouse and field grown transgenic tobacco plants [PDF]
, 2018 Photorespiration is essential for C3 plants, enabling oxygenic photosynthesis through the scavenging of 2‐phosphoglycolate. Previous studies have demonstrated that overexpression of the L‐ and H‐proteins of the photorespiratory glycine cleavage system ...
Brown, Kenny L +5 more
core +2 more sources
Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components [PDF]
, 2015 Individual recombinant components of pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes (PDHc, OGDHc) of human and Escherichia coli (E. coli) origin were expressed and purified from E. coli with optimized protocols.
Adam-Vizi +123 more
core +1 more source
Molecular mechanisms of mitochondrial de novo [2Fe-2S] cluster formation and lipoyl biosynthesis [PDF]
, 2023 Iron-sulfur (Fe/S) clusters are small inorganic protein cofactors found in almost all known organisms. They enable various protein functions including electron transfer and catalysis and are integral to numerous essential biological processes like ...
Schulz, Vinzent
core +1 more source
Lipoamidase (lipoyl-X hydrolase) from pig brain [PDF]
Biochemical Journal, 1990 Although the optimum substrate for lipoamidase (lipoyl-X hydrolase) has not yet been determined, it is known that lipoamidase activity, as determined by hydrolysis of the synthetic substrate lipoyl 4-aminobenzoate (LPAB), is widely distributed in pig brain tissues, i.e. in the cerebrum, cerebellum and medulla. Over 95% of the enzyme activity is present
J, Oizumi, K, Hayakawa
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Nature Communications, 2023 Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty acid products has remained unclear.
M. Tanvir Rahman +8 more
doaj +1 more source