Results 31 to 40 of about 3,490 (194)
Nature Communications, 2023 Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty acid products has remained unclear.
M. Tanvir Rahman +8 more
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Frontiers in Chemistry, 2021 Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very ...
Sun Liu Rei Yan +4 more
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Proteomic analysis reveals a novel function of the kinase Sat4p in Saccharomyces cerevisiae mitochondria. [PDF]
PLoS ONE, 2014 The Saccharomyces cerevisiae kinase Sat4p has been originally identified as a protein involved in salt tolerance and stabilization of plasma membrane transporters, implicating a cytoplasmic localization. Our study revealed an additional mitochondrial (mt)
Uta Gey +4 more
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Lipoyl-E2-PDH Gets a Second Job [PDF]
Cell Host & Microbe, 2017 Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress TLR-mediated activation of host macrophages by bacterial lipoproteins.
Seth W, Dickey, Michael, Otto
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Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
eLife, 2020 Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS).
Sara M Nowinski +18 more
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Frontiers in Plant Science, 2021 Lipoic acid (LA, 6,8-dithiooctanoic acid) is a sulfur containing coenzyme essential for the activity of several key enzymes involved in oxidative and single carbon metabolism in most bacteria and eukaryotes. LA is synthetized by the concerted activity of
Raquel Martins-Noguerol +8 more
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Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.
PLoS Pathogens, 2007 Lipoic acid (LA) is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Svenja Günther +8 more
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Nature Communications, 2023 Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S.
Wen Fang +8 more
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Journal of Biological Chemistry, 1966 Abstract The sensitivity of lipoyl dehydrogenase to phenylmercuric acetate, a reagent for —SH groups, has been investigated. Titration of available sulfhydryl groups in the enzyme brings about inactivation in the reduced diphosphopyridine nucleotide-lipoyl reductase activity, while activity with the artificial hydrogen acceptor 2,6-dichloroindophenol ...
L, Casola, V, Massey
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Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes
mBio, 2017 Lipoic acid is an essential metabolic cofactor added as a posttranslational modification on several multimeric enzyme complexes. These protein complexes, evolutionarily conserved from bacteria to humans, are core regulators of cellular metabolism.
Elizabeth A. Rowland +5 more
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