Expression and lipoylation in Escherichia coli of the inner lipoyl domain of the E2 component of the human pyruvate dehydrogenase complex [PDF]
Biochemical Journal, 1993 openalex +4 more sources
Lipoylation Mechanism of P. Falciparum Mitochondrial Proteins [PDF]
Biophysical Journal, 2015 Lipoate is an essential cofactor for the aerobic metabolism in oxidative decarboxylation reactions of 2-oxoacid complexes. Malaria parasite survival is highly dependent on scavenging this essential cofactor from the human host. Scavenged lipoate is subsequently attached to the α-ketoglutarate dehydrogenase (KDH), the branched chain α-ketoacid ...
Alfredo J. Guerra +3 more
openalex +3 more sources
Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast-Like Synoviocyte. [PDF]
Int J Rheum DisABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic synovitis and skeletal joint deformities, often accompanied by systemic symptoms. Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids ...
Zhi X +5 more
europepmc +2 more sources
Frontiers in Medicine, 2022 Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu +12 more
doaj +1 more source
Lipoylation of Acyltransferase Components of α-Ketoacid Dehydrogenase Complexes [PDF]
Journal of Biological Chemistry, 1996 Lipoic acid is a prosthetic group of the acyltransferase components of the pyruvate, alpha-ketoglutarate, and branched chain alpha-ketoacid dehydrogenase complexes, protein X of the eukaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system.
Kazuko Fujiwara +2 more
openalex +5 more sources
Frontiers in Plant Science, 2020 Plants intensely modulate respiration when pathogens attack, but the function of mitochondrial respiration-related genes in plant–bacteria interaction is largely unclear.
Qiaomei Ma +6 more
doaj +1 more source
FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis
Heliyon, 2023 Cuprotosis is a recently identified cell death form that caused by intracellular copper accumulation and regulated by FDX1. This work aimed to explore the role of cuprotosis and the pivotal regulatory gene FDX1 in thyroid cancer development.
Gaoxiang Chen +4 more
doaj +1 more source
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer. [PDF]
Adv Sci (Weinh)This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Sun Z +10 more
europepmc +2 more sources
Novel insights into the Thaumarchaeota in the deepest oceans: their metabolism and potential adaptation mechanisms [PDF]
, 2020 Background: Marine Group I (MGI) Thaumarchaeota, which play key roles in the global biogeochemical cycling of nitrogen and carbon (ammonia oxidizers), thrive in the aphotic deep sea with massive populations.
Lehtovirta-Morley, Laura +8 more
core +2 more sources
Molecular mechanisms of mitochondrial de novo [2Fe-2S] cluster formation and lipoyl biosynthesis [PDF]
, 2023 Iron-sulfur (Fe/S) clusters are small inorganic protein cofactors found in almost all known organisms. They enable various protein functions including electron transfer and catalysis and are integral to numerous essential biological processes like ...
Schulz, Vinzent
core +1 more source