Results 31 to 40 of about 4,213 (194)

Clinical and genetic aspects of defects in the mitochondrial iron-sulfur cluster synthesis pathway [PDF]

open access: yes, 2018
Iron-sulfur clusters are evolutionarily conserved biological structures which play an important role as cofactor for multiple enzymes in eukaryotic cells.
Van Coster, Rudy, Vanlander, Arnaud
core   +2 more sources

Mutation of the palmitoylation site of estrogen receptor alpha in vivo reveals tissue-specific roles for membrane versus nuclear actions [PDF]

open access: yes, 2014
Estrogen receptor alpha (ERalpha) activation functions AF-1 and AF-2 classically mediate gene transcription in response to estradiol (E2). A fraction of ERalpha is targeted to plasma membrane and elicits membrane-initiated steroid signaling (MISS), but ...
A. Abot   +19 more
core   +2 more sources

Molecular mechanisms of mitochondrial de novo [2Fe-2S] cluster formation and lipoyl biosynthesis [PDF]

open access: yes, 2023
Iron-sulfur (Fe/S) clusters are small inorganic protein cofactors found in almost all known organisms. They enable various protein functions including electron transfer and catalysis and are integral to numerous essential biological processes like ...
Schulz, Vinzent
core   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

open access: yes, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I.   +7 more
core   +4 more sources

Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency [PDF]

open access: yes, 2015
Disorders of the mitochondrial energy metabolism are clinically and genetically heterogeneous. An increasingly recognized subgroup is caused by defective mitochondrial iron-sulfur (Fe-S) cluster biosynthesis, with defects in 13 genes being linked to ...
Angela eHagendorff   +26 more
core   +3 more sources

Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae [PDF]

open access: yes, 2013
Background: Acetic acid is mostly known as a toxic by-product of alcoholic fermentation carried out by Saccharomyces cerevisiae, which it frequently impairs. The more recent finding that acetic acid triggers apoptotic programmed cell death (PCD) in yeast
Chaves, S. R.   +7 more
core   +2 more sources

Functional Identification and Structural Analysis of a New Lipoate Protein Ligase in Mycoplasma hyopneumoniae [PDF]

open access: yes, 2020
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of pandemic pneumonia among pigs, namely, swine enzootic pneumonia. Although M. hyopneumoniae was first identified in 1965, little is known regarding its metabolic pathways, which might ...
CHEN, H   +9 more
core   +1 more source

Targeted next generation sequencing in patients with inborn errors of metabolism [PDF]

open access: yes, 2018
BACKGROUND: Next-generation sequencing (NGS) technology has allowed the promotion of genetic diagnosis and are becoming increasingly inexpensive and faster.
Armstrong i Morón, Judith   +9 more
core   +1 more source

Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases [PDF]

open access: yes, 2022
Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial roles in cellular metabolism.
Arp, Nicholas L   +5 more
core   +2 more sources

Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae [PDF]

open access: yes, 2016
Schematic diagrams of inserts within the fliDCAZ loci of FGI−/FMI− Enterobacteriaceae. Flanking genes are indicated by yellow arrows, predicted phage genes by blue arrows, fimbrial biogenesis genes by grey arrows and sugar/amino acid transporter genes by
Don A. Cowan, Pieter De Maayer
core   +3 more sources

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