Results 51 to 60 of about 4,213 (194)
Cell Proliferation, EarlyView.PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie +8 more
wiley +1 more source
Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation. [PDF]
, 2018 Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with their proposed model based on the following reasons.Wellcome 102770/Z/13/Z and 205252/Z/16/Z ...
Bailey, Peter SJ +4 more
core +1 more source
Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred
Protein Science, Volume 35, Issue 2, February 2026.Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong +2 more
wiley +1 more source
Small Structures, Volume 7, Issue 1, January 2026.Chirality‐directed strategy designed by copper‐based nanoregulator (Cu‐D‐Car@HA) to potentiate collaborative cuproptosis‐immunotherapy by overcoming tumor resistance to cuproptosis highlights a materials‐based method for superior cuproptosis‐immunotherapy.
Hao Zhou +8 more
wiley +1 more source
Unravelling the lipoyl‐relay of exogenous lipoate utilization in Bacillus subtilis [PDF]
, 2019 Lipoate is an essential cofactor for key enzymes of oxidative and one-carbon metabolism. It is covalently attached to E2 subunits of dehydrogenase complexes and GcvH, the H subunit of the glycine cleavage system.
Ausubel F.M. +5 more
core +1 more source
Progress of Programmed Cell Death in Steroid‐Induced Osteonecrosis of the Femoral Head
Orthopaedic Surgery, Volume 18, Issue 1, Page 16-30, January 2026.Steroid‐induced osteonecrosis of the femoral head is a severe osteoarticular condition resulting from glucocorticoid overuse, characterized by femoral head bone structure collapse and cell death, now predominant among nontraumatic femoral head necroses.
Zhi Kong, Chao Han
wiley +1 more source
FDX1 regulates cellular protein lipoylation through direct binding to LIAS [PDF]
, 2023 Margaret Dreishpoon +8 more
openalex +1 more source
Lipoylation of Acyltransferase Components of α-Ketoacid Dehydrogenase Complexes [PDF]
Journal of Biological Chemistry, 1996 Lipoic acid is a prosthetic group of the acyltransferase components of the pyruvate, alpha-ketoglutarate, and branched chain alpha-ketoacid dehydrogenase complexes, protein X of the eukaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system.
K, Fujiwara +2 more
openaire +2 more sources
Impairment of lipoylation mediated by bromooctanoate targets eukaryotic amidotransferases [PDF]
Molecular MicrobiologyABSTRACTLipoylation is a post‐translational modification in which lipoic acid is attached to specific apoproteins of enzyme complexes, like E2 subunits of dehydrogenases or GcvH of the glycine cleavage system. A defining feature of organisms with a lipoyl‐relay system is the presence of amidotransferase activity, which enables the transfer of lipoyl ...
Albertina Scattolini +4 more
openalex +2 more sources
Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.ABSTRACT Long non‐coding RNAs (lncRNAs) play important roles in colorectal cancer (CRC) progression. However, the biological function and regulatory mechanism of small nucleolar RNA host gene 26 (SNHG26) in CRC remain largely unexplored. SNHG26 expression was analysed in CRC tissues and cell lines using quantitative real‐time PCR (qRT‐PCR).
Ziang Wan, Shan Gao
wiley +1 more source