Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.
PLoS Pathogens, 2007 Lipoic acid (LA) is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Svenja Günther +8 more
doaj +1 more source
Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
, 2011 <p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I. +7 more
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Crystallographic snapshots of sulfur insertion by lipoyl synthase [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Lipoic acid, an enzyme cofactor in central metabolism and a livestock feed supplement, is produced on an industrial scale by a costly multistep synthesis. Nature makes lipoic acid in one step by the chemically challenging addition of two sulfur atoms to an inert fatty acid chain.
Nicholas D. Lanz +7 more
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Evidence for two protein‐lipoylation activities in Escherichia coli [PDF]
FEBS Letters, 1991 The lipoate acyltransferase subunits of the 2‐oxo acid dehydrogenase complexes are post‐translationally modified with one or more covalently‐bound lipoyl cofactors. Two distinct lipoate‐protein ligase activities, LPL‐A and LPL‐B, have been detected in E. coli by their ability to modify purified lipoyl apo‐domains of the bacterial pyruvate dehydrogenase
Dawn E. Brookfield +4 more
openalex +5 more sources
Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency [PDF]
, 2015 Disorders of the mitochondrial energy metabolism are clinically and genetically heterogeneous. An increasingly recognized subgroup is caused by defective mitochondrial iron-sulfur (Fe-S) cluster biosynthesis, with defects in 13 genes being linked to ...
Angela eHagendorff +26 more
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Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases [PDF]
, 2022 Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial roles in cellular metabolism.
Arp, Nicholas L +5 more
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Journal of Biological Chemistry, 1969 Abstract Lipoyl dehydrogenase (NADH:lipoamide oxidoreductase, EC 1.6.4.3), highly purified from pig brain, is similar in physical and kinetic properties to the enzyme from other mammalian sources. Lipoyl dehydrogenase is markedly inhibited by pteridines, but its transhydrogenase and diaphorase activities are unaffected.
Kubose A, Gál Em, Millard Sa
openaire +3 more sources
Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae [PDF]
, 2013 Background: Acetic acid is mostly known as a toxic by-product of alcoholic fermentation carried out by Saccharomyces cerevisiae, which it frequently impairs. The more recent finding that acetic acid triggers apoptotic programmed cell death (PCD) in yeast
Chaves, S. R. +7 more
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Glutarate regulates T cell metabolism and anti-tumour immunity [PDF]
, 2023 T cell function and fate can be influenced by several metabolites: in some cases, acting through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through post-translational modification of lysines in important targets.
Antrobus, Robin +16 more
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