Results 51 to 60 of about 4,273 (194)

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Cell Reports, 2019
Summary: Inborn errors of metabolism (IEMs) link metabolic defects to human phenotypes. Modern genomics has accelerated IEM discovery, but assessing the impact of genomic variants is still challenging.
Min Ni, Ashley Solmonson, Chunxiao Pan, Chendong Yang, Dan Li, Ashley Notzon, Ling Cai, Gerardo Guevara, Lauren G. Zacharias, Brandon Faubert, Hieu S. Vu, Lei Jiang, Bookyung Ko, Noriko Merida Morales, Jimin Pei, Gonçalo Vale, Dinesh Rakheja, Nick V. Grishin, Jeffrey G. McDonald, Garrett K. Gotway, Markey C. McNutt, Juan M. Pascual, Ralph J. DeBerardinis   +22 more
doaj   +1 more source

Glutarate regulates T cell metabolism and anti-tumour immunity [PDF]

, 2023
T cell function and fate can be influenced by several metabolites: in some cases, acting through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through post-translational modification of lysines in important targets.
Antrobus, Robin, Barbieri, Laura, Bargiela, David, Cunha, Pedro P., Foskolou, Iosifina P., Grice, Guinevere L., Hughes, Rob, Johnson, Randall S., Koivunen, Peppi, Minogue, Eleanor, Nathan, James A., Quaranta, Alessandro, Sah-Teli, Shiv K., Velica, Pedro, Wadsworth, Brennan J., Wheelock, Craig E., Zurita, Javier   +16 more
core   +1 more source

Crystal structure of lipoate‐bound lipoate ligase 1, LipL1, from Plasmodium falciparum [PDF]

, 2017
Plasmodium falciparum lipoate protein ligase 1 (PfLipL1) is an ATP‐dependent ligase that belongs to the biotin/lipoate A/B protein ligase family (PFAM PF03099).
Afanador, Gustavo A., Guerra, Alfredo J., Prigge, Sean T.   +2 more
core   +1 more source

Defining Caenorhabditis elegans as a model system to investigate lipoic acid metabolism [PDF]

, 2020
Lipoic acid (LA) is a sulfur-containing cofactor that covalently binds to a variety of cognate enzymes that are essential for redox reactions in all three domains of life.
de Mendoza, Diego, Lavatelli, Antonela, Mansilla, Maria Cecilia   +2 more
core   +1 more source

Distinctive phosphoinositide- and Ca²⁺-binding properties of normal and cognitive performance–linked variant forms of KIBRA C2 domain [PDF]

, 2018
Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking.
Bagby, S, Crennell, SJ, Harris, G, Ishima, R, Kalli, AC, Kremerskothen, J, Posner, MG, Sansom, MSP, Upadhyay, A   +8 more
core   +2 more sources

Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma

Frontiers in Oncology, 2022
Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death.
Qin Hu, Qin Hu, Runtian Wang, Huiyun Ma, Huiyun Ma, Zhouwei Zhang, Zhouwei Zhang, Qun Xue   +7 more
doaj   +1 more source

An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid Proteins

, 2015
Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria.
Agrawal, Swati, Brooks, Carrie F., Chung, Duk-Won D., Ferdig, Michael T., Le Roch, Karine G., Ponts, Nadia, Prudhomme, Jacques, Rodrigues, Elisadra M., Striepen, Boris, Tan, John C., van Dooren, Giel G.   +10 more
core   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Richard Nelson Perham. 27 April 1937—14 February 2015 [PDF]

, 2018
Richard Nelson Perham, FRS, FMedSci, FRSA, was a British professor of structural biochemistry. He undertook his academic career at the University of Cambridge, holding positions as lecturer, reader, chair and head of the Department of Biochemistry, as ...
Aikens R., Hale G., Radford S. E., Steven A. C., Wilson T. M. A., Wilson T. M. A.   +5 more
core   +3 more sources