Results 91 to 100 of about 6,019,478 (263)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Dynamics Simulation of Binary liquid mixture Phase Separation and Glass Transition
Chemical Engineering Transactions, 2018 This paper aims to study the phase separation of binary liquid mixture and two-phase glass transition process by using the method of molecular dynamics (MD) simulation.
Meili Li, Xingye Fu
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Controlling the morphological and electro-optical properties of polymer dispersed Liquid crystals [PDF]
, 2008 Polymer dispersed liquid crystals have shown potential as the basis for a new display screen technology which can be used to produce flexible displays.
Folkes, Robert L., Folkes, Robert L
core
Oil/water separation in a liquid-liquid cylindrical cyclone
, 2012 The oil/water separation in a liquid-liquid cylindrical cyclone is experimentally studied in this article. The effects of the flow split-ratio and the flow rate on the oil/water separation performance are determined.
Chinese Acad Sci, Inst Mech, Key Lab Hydrodynam & Ocean Engn, Beijing 100190, Peoples R China. +7 more
core +1 more source
Tailoring Multiphasic Protein Condensates via Liquid‐Liquid Phase Separation
AggregateMany of the membraneless organelles inside cells are multiphasic condensates with complex structural organizations driven by the demixing of phase‐separating proteins.
Yongxu Han +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Liquid-liquid crystalline phase separation of spider silk proteins
Communications ChemistryLiquid-liquid phase separation (LLPS) of proteins can be considered an intermediate solubility regime between disperse solutions and solid fibers.
Michael Landreh +5 more
doaj +1 more source