Results 91 to 100 of about 342,327 (294)

Liquid-liquid phase separation and solidification behavior of Al-Bi-Sb immiscible alloys

Results in Physics, 2017
In this study, the liquid-liquid phase separation of three kinds of ternary immiscible Al-Bi-Sb melts was investigated with resistivity and thermodynamics method.
Degang Zhao, Rongxue Liu, Di Wu, Lin Bo, Lin Wang   +4 more
doaj   +1 more source

Effect of nuclear import receptors on liquid–liquid phase separation

Biophysics and Physicobiology, 2020
Low-complexity (LC) sequences, regions that are predominantly made up of limited amino acids, are often observed in eukaryotic nuclear proteins. The role of these LC sequences has remained unclear for decades.
Takuya Yoshizawa, Hiroyoshi Matsumura
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Hydrodynamic and mass transfer in inertial gas–liquid flow regimes through straight and meandering millimetric square channels [PDF]

, 2011
Heat-exchanger reactors are an important part of process intensification technology. For plate geometries, one solution for intensifying transfer and increasing residence times is to construct two-dimensional meandering channels.
Michel Cabassud, Cabassud, Michel, Loubière, Karine, Karine Loubiere, Christophe Gourdon, Matthieu Roudet, Roudet, Matthieu, Gourdon, Christophe   +7 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Residence time distribution measurements in an external-loop airlift reactor: Study of the hydrodynamics of the liquid circulation induced by the hydrogen bubbles [PDF]

, 2011
A detailed study of the residence time distribution (RTD) analysis of liquid phase has been performed in an external-loop airlift reactor of 20 L nominal volume, regarded as a global unit and discriminating its different sections (riser, gas–liquid ...
A.H. Essadki, Vial, Christophe, Gourich, Bouchaib, Ch. Vial, H. Delmas, Essadki, Abdel Hafid, Delmas, Henri, B. Gourich   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Análise teórico-experimental de separadores de fases para refrigeração doméstica [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2015A utilização de ciclos com separadores de fases, também conhecidos em inglês como flash gas by-pass ...
Mello, Ianary Quadros de
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source