Results 81 to 90 of about 923,622 (282)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Liquid–liquid phase separation in particles containing organics mixed with ammonium sulfate, ammonium bisulfate, ammonium nitrate or sodium chloride [PDF]

Atmospheric Chemistry and Physics, 2013
As the relative humidity varies from high to low values in the atmosphere, particles containing organic species and inorganic salts may undergo liquid–liquid phase separation.
Y. You, L. Renbaum-Wolff, A. K. Bertram
doaj   +1 more source

Criticality in strongly correlated fluids

, 2001
In this brief review I will discuss criticality in strongly correlated fluids. Unlike simple fluids, molecules of which interact through short ranged isotropic potential, particles of strongly correlated fluids usually interact through long ranged forces
Bjerrum N, Brush S G, Clausius R, de Gennes P G, de Laplace P S, Debye P W, Fisher M E, Gibbs J W, Maxwell J C, Newton I 1687, Newton I 1730, Panagiotopoulos A Z, Pitzer K S, Rushbrooke G S, Tavares J M, Tavares J M, van der Waals J D, Wertheim M S, Wilson K G, Yan Levin   +19 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Liquid-liquid phase separation and solidification behavior of Al-Bi-Sb immiscible alloys

Results in Physics, 2017
In this study, the liquid-liquid phase separation of three kinds of ternary immiscible Al-Bi-Sb melts was investigated with resistivity and thermodynamics method.
Degang Zhao, Rongxue Liu, Di Wu, Lin Bo, Lin Wang   +4 more
doaj   +1 more source

Real-Gas Effects and Phase Separation in Underexpanded Jets at Engine-Relevant Conditions

, 2018
A numerical framework implemented in the open-source tool OpenFOAM is presented in this work combining a hybrid, pressure-based solver with a vapor-liquid equilibrium model based on the cubic equation of state.
Baab S., Bhaskar V. V. N., Bloomer O. T., Chang S., Cines M. R., Elliott J. R., Firoozabadi A., Goos E., Issa R. I., Kraposhin M. V., Lüdecke D., Matheis J., Mausbach P., Michelsen M. L., Min B. H., Poling B. E., Reid R. C., Wood A. B.   +17 more
core   +1 more source

Liquid–liquid phase separation during amphiphilic self-assembly [PDF]

Nature Chemistry, 2019
The self-assembly of amphiphilic molecules in solution is a ubiquitous process in both natural and synthetic systems. The ability to effectively control the structure and properties of these systems is essential for tuning the quality of their functionality, yet the underlying mechanisms governing the transition from molecules to assemblies have not ...
Alessandro Ianiro, Hanglong Wu, Mark M. J. van Rijt, M. Paula Vena, Arthur D. A. Keizer, A. Catarina C. Esteves, Remco Tuinier, Heiner Friedrich, Nico A. J. M. Sommerdijk, Joseph P. Patterson   +9 more
openaire   +5 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Effect of nuclear import receptors on liquid–liquid phase separation

Biophysics and Physicobiology, 2020
Low-complexity (LC) sequences, regions that are predominantly made up of limited amino acids, are often observed in eukaryotic nuclear proteins. The role of these LC sequences has remained unclear for decades.
Takuya Yoshizawa, Hiroyoshi Matsumura
doaj   +1 more source