Results 261 to 270 of about 342,327 (294)
Some of the next articles are maybe not open access.
Liquid–Liquid Phase Separation in Disease
Annual Review of Genetics, 2019We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ability to develop effective disease treatments.
Alberti, Simon, Dormann, Dorothee
openaire +3 more sources
Liquid–Liquid Phase Separation? Ask the Water!
The Journal of Physical Chemistry Letters, 2023Water is more than an inert spectator during liquid-liquid phase separation (LLPS), the reversible compartmentalization of protein solutions into a protein-rich and a dilute phase. We show that LLPS is driven by changes in hydration entropy and enthalpy. Tuning LLPS by adjusting experimental parameters, e.g., addition of co-solutes, is a major goal for
Pezzotti, Simone +4 more
openaire +2 more sources
Liquid-Liquid phase separation in bacteria
Microbiological ResearchCells are the essential building blocks of living organisms, responsible for carrying out various biochemical reactions and performing specific functions. In eukaryotic cells, numerous membrane organelles have evolved to facilitate these processes by providing specific spatial locations.
Dong, Guo +5 more
openaire +2 more sources
Spontaneous liquid-liquid phase separation of water
Physical Review E, 2014We report a molecular dynamics simulation demonstrating a fast spontaneous liquid-liquid phase separation of water and a subsequent slow crystallization to ice. It is found that supercooled water separates rapidly into low- and high-density domains so as to reduce the surface energy in the rectangular simulation cell at certain thermodynamic states ...
Takuma, Yagasaki +2 more
openaire +2 more sources
Morphology of Liquid–Liquid Phase Separated Aerosols
Journal of the American Chemical Society, 2015The morphology of liquid-liquid phase separated aerosols has a strong impact on their rate of gas and water uptake, and the type and rate of heterogeneous reactions in the atmosphere. However, it is extremely challenging to experimentally distinguish different morphologies (core-shell or partial wetting) of aerosols and to quantify the extent of ...
Yuqing, Qiu, Valeria, Molinero
openaire +2 more sources
Liquid–liquid phase separation in innate immunity
Trends in ImmunologyIntrinsic and innate immune responses are essential lines of defense in the body's constant surveillance of pathogens. The discovery of liquid-liquid phase separation (LLPS) as a key regulator of this primal response to infection brings an updated perspective to our understanding of cellular defense mechanisms. Here, we review the emerging multifaceted
Dawei Liu +2 more
openaire +2 more sources
Liquid–liquid phase separation in micropores
Current Applied Physics, 2004Phase separation of binary liquids with an upper critical temperature in porous materials is studied by H-1 NMR cryoporometry and cross-relaxation spectroscopy and by N-15 NMR spectroscopy.
Rustem Valiullin +2 more
openaire +4 more sources
Liquid–liquid phase separation in Alzheimer’s disease
Journal of Molecular MedicineThe pathological aggregation and misfolding of tau and amyloid-β play a key role in Alzheimer's disease (AD). However, the underlying pathological mechanisms remain unclear. Emerging evidences indicate that liquid-liquid phase separation (LLPS) has great impacts on regulating human health and diseases, especially neurodegenerative diseases. A series of
Qinggang Fu +3 more
openaire +2 more sources
Crystallization in the Presence of a Liquid−Liquid Phase Separation
Organic Process Research & Development, 2006This paper presents and compares crystallization experiments of an active pharmaceutical ingredient and a biological molecule in the presence of a liquid−liquid phase separation monitored by in situ video. The advantage of this setup is that it requires a small quantity of these products to study the influence of the physicochemical parameters on ...
Veesler, S. +3 more
openaire +2 more sources
Dynamics of Liquid–Liquid Phase Separation in Submicrometer Aerosol
The Journal of Physical Chemistry A, 2021Nanoscale materials, when compared to their bulk components, possess unique properties. In particular, shifts in phase transitions can occur for submicrometer particles. For instance, small particles do not undergo the process of liquid-liquid phase separation (LLPS).
Theresa M. Kucinski +2 more
openaire +2 more sources