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Liquid–liquid phase separation in micropores
Current Applied Physics, 2004Phase separation of binary liquids with an upper critical temperature in porous materials is studied by H-1 NMR cryoporometry and cross-relaxation spectroscopy and by N-15 NMR spectroscopy.
Rustem Valiullin +2 more
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Liquid–liquid phase separation in Alzheimer’s disease
Journal of Molecular MedicineThe pathological aggregation and misfolding of tau and amyloid-β play a key role in Alzheimer's disease (AD). However, the underlying pathological mechanisms remain unclear. Emerging evidences indicate that liquid-liquid phase separation (LLPS) has great impacts on regulating human health and diseases, especially neurodegenerative diseases. A series of
Qinggang Fu +3 more
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Evidence for and against Liquid-Liquid Phase Separation in the Nucleus [PDF]
Non-coding RNA, 2019 Enclosed by two membranes, the nucleus itself is comprised of various membraneless compartments, including nuclear bodies and chromatin domains. These compartments play an important though still poorly understood role in gene regulation. Significant progress has been made in characterizing the dynamic behavior of nuclear compartments and liquid-liquid ...
Stephanie C Weber
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Liquid–liquid phase separation in cellular signaling systems
Current Opinion in Structural Biology, 2016Liquid-liquid demixing or phase separation of protein with RNA is now recognized to be a key part of the mechanism for assembly of ribonucleoprotein granules. Cellular signaling also appears to employ phase separation as a mechanism for amplification or control of signal transduction both within the cytoplasm and at the membrane.
P Andrew, Chong, Julie D, Forman-Kay
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Protein Folding, Aggregation, and Liquid-Liquid Phase Separation
Current Protein & Peptide ScienceMai Suan Li +2 more
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Liquid–liquid phase separation in presynaptic nerve terminals
Trends in Biochemical SciencesThe presynaptic nerve terminal is crucial for transmitting signals to the adjacent cell. To fulfill this role, specific proteins with distinct functions are concentrated in spatially confined areas within the nerve terminals. A recent concept termed liquid-liquid phase separation (LLPS) has provided new insights into how this process may occur. In this
Jiyoung Choi +2 more
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Liquid–liquid phase separation induced auto-confinement
Soft MatterLiquid-liquid phase separation induced auto-confinement allows macromolecules to attain arrangements typically unachievable through conventional self-assembly processes.
Aoon Rizvi, Joseph P. Patterson
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Heterogeneity of Molecular Crowding and Liquid-Liquid Phase Separation
The inside of a living cell is highly crowded with extremely diverse biomacromolecules, small metabolites and osmolytes. The molecular conditions in cells change dynamically and rapidly depending on the cell cycle and state, organelle, and compartment.Mitsuki, Tsuruta +3 more
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Liquid–liquid phase separation in pharmaceutical crystallization
Chemical Engineering Research and Design, 2021Fangkun Zhang, Zai-Qun Yu
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