Results 241 to 250 of about 923,622 (282)

Computer Simulations Show That Liquid-Liquid Phase Separation Enhances Self-Assembly. [PDF]

ACS Nano
Frechette LB, Sundararajan N, Caballero F, Trubiano A, Hagan MF.   +4 more
europepmc   +1 more source

Stress-Induced Membraneless Organelles in Neurons: Bridging Liquid-Liquid Phase Separation and Neurodevelopmental Dysfunction. [PDF]

Int J Mol Sci
Bencsik N, Kimsanaliev D, Tárnok K, Schlett K.   +3 more
europepmc   +1 more source

Distinct liquid-liquid phase separation properties of end-binding proteins EB1 and EB3. [PDF]

J Biol Chem
Boyko S, Li Q, Surewicz K, Surewicz WK.
europepmc   +1 more source

In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA

Basse V, Agarwal T, Sneideris T, Richard C, Troussier J, Vasseur J, Debart F, Eléouët J, de Csillery E, Knowles T, Galloux M.   +10 more
europepmc   +1 more source

CpG-A induces liquid-liquid phase separation of HMGB1 to activate the RAGE-mediated inflammatory pathway. [PDF]

Proc Natl Acad Sci U S A
Peng K, Fu G, Chen L, Xie J, Bao K, Li JP, Luo SZ.   +6 more
europepmc   +1 more source

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Liquid-Liquid Phase Separation in Biology

Annual Review of Cell and Developmental Biology, 2014
Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.
Hyman, Anthony A., Weber, Christoph A., Jülicher, Frank   +2 more
openaire   +7 more sources

Liquid–Liquid Phase Separation in Chromatin

Cold Spring Harbor Perspectives in Biology, 2021
In eukaryotic cells, protein and RNA factors involved in genome activities like transcription, RNA processing, DNA replication, and repair accumulate in self-organizing membraneless chromatin subcompartments. These structures contribute to efficiently conduct chromatin-mediated reactions and to establish specific cellular programs.
openaire   +2 more sources

Liquid-liquid Phase Separation in Viral Function

Journal of Molecular Biology, 2023
An emerging set of results suggests that liquid-liquid phase separation (LLPS) is the basis for the formation of membrane-less compartments in cells. Evidence is now mounting that various types of virus-induced membrane-less compartments and organelles are also assembled via LLPS.
Xiaoyue, Zhang, Run, Zheng, Zhengshuo, Li, Jian, Ma   +3 more
openaire   +2 more sources

Liquid–Liquid Phase Separation in Disease

Annual Review of Genetics, 2019
We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ability to develop effective disease treatments.
Alberti, Simon, Dormann, Dorothee
openaire   +3 more sources

Liquid–Liquid Phase Separation? Ask the Water!

The Journal of Physical Chemistry Letters, 2023
Water is more than an inert spectator during liquid-liquid phase separation (LLPS), the reversible compartmentalization of protein solutions into a protein-rich and a dilute phase. We show that LLPS is driven by changes in hydration entropy and enthalpy. Tuning LLPS by adjusting experimental parameters, e.g., addition of co-solutes, is a major goal for
Pezzotti, Simone, König, Benedikt, Ramos, Sashary, Schwaab, Gerhard, Havenith, Martina   +4 more
openaire   +2 more sources