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Tau liquid–liquid phase separation in neurodegenerative diseases
Trends in Cell Biology, 2022Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's disease and several other neurodegenerative disorders. An exciting recent development is the finding that, akin to some other proteins associated with neurodegenerative disease, tau has a high propensity to condensate via the mechanism of liquid-liquid phase ...
Witold Surewicz, Solomiia Boyko
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Liquid–Liquid Phase Separation in Chromatin
Cold Spring Harbor Perspectives in Biology, 2021In eukaryotic cells, protein and RNA factors involved in genome activities like transcription, RNA processing, DNA replication, and repair accumulate in self-organizing membraneless chromatin subcompartments. These structures contribute to efficiently conduct chromatin-mediated reactions and to establish specific cellular programs.
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Liquid–Liquid Phase Separation? Ask the Water!
The Journal of Physical Chemistry Letters, 2023Water is more than an inert spectator during liquid-liquid phase separation (LLPS), the reversible compartmentalization of protein solutions into a protein-rich and a dilute phase. We show that LLPS is driven by changes in hydration entropy and enthalpy. Tuning LLPS by adjusting experimental parameters, e.g., addition of co-solutes, is a major goal for
Pezzotti, Simone +4 more
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Liquid–Liquid Phase Separation in Disease
Annual Review of Genetics, 2019We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ability to develop effective disease treatments.
Alberti, Simon, Dormann, Dorothee
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Liquid-Liquid phase separation in bacteria
Microbiological ResearchCells are the essential building blocks of living organisms, responsible for carrying out various biochemical reactions and performing specific functions. In eukaryotic cells, numerous membrane organelles have evolved to facilitate these processes by providing specific spatial locations.
Dong, Guo +5 more
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Spontaneous liquid-liquid phase separation of water
Physical Review E, 2014We report a molecular dynamics simulation demonstrating a fast spontaneous liquid-liquid phase separation of water and a subsequent slow crystallization to ice. It is found that supercooled water separates rapidly into low- and high-density domains so as to reduce the surface energy in the rectangular simulation cell at certain thermodynamic states ...
Takuma, Yagasaki +2 more
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Morphology of Liquid–Liquid Phase Separated Aerosols
Journal of the American Chemical Society, 2015The morphology of liquid-liquid phase separated aerosols has a strong impact on their rate of gas and water uptake, and the type and rate of heterogeneous reactions in the atmosphere. However, it is extremely challenging to experimentally distinguish different morphologies (core-shell or partial wetting) of aerosols and to quantify the extent of ...
Yuqing, Qiu, Valeria, Molinero
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Applications of Liquid–Liquid Phase Separation in Biosensing
ChemBioChemAbstractPhase separation, particularly liquid‐liquid phase separation (LLPS), has emerged as a powerful tool in biological research, offering unique advantages for visualizing and analyzing biomolecular interactions. This review highlights recent advances in leveraging LLPS to develop experimental techniques for studying protein‐protein interactions ...
Huizhen Huang, Jun Hu
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Crystallization in the Presence of a Liquid−Liquid Phase Separation
Organic Process Research & Development, 2006This paper presents and compares crystallization experiments of an active pharmaceutical ingredient and a biological molecule in the presence of a liquid−liquid phase separation monitored by in situ video. The advantage of this setup is that it requires a small quantity of these products to study the influence of the physicochemical parameters on ...
Veesler, S. +3 more
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Liquid–liquid phase separation in innate immunity
Trends in ImmunologyIntrinsic and innate immune responses are essential lines of defense in the body's constant surveillance of pathogens. The discovery of liquid-liquid phase separation (LLPS) as a key regulator of this primal response to infection brings an updated perspective to our understanding of cellular defense mechanisms. Here, we review the emerging multifaceted
Dawei Liu +2 more
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