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Spontaneous liquid-liquid phase separation of water
Physical Review E, 2014We report a molecular dynamics simulation demonstrating a fast spontaneous liquid-liquid phase separation of water and a subsequent slow crystallization to ice. It is found that supercooled water separates rapidly into low- and high-density domains so as to reduce the surface energy in the rectangular simulation cell at certain thermodynamic states ...
Takuma, Yagasaki +2 more
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Liquid-Liquid phase separation in bacteria
Microbiological ResearchCells are the essential building blocks of living organisms, responsible for carrying out various biochemical reactions and performing specific functions. In eukaryotic cells, numerous membrane organelles have evolved to facilitate these processes by providing specific spatial locations.
Dong, Guo +5 more
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Tau liquid–liquid phase separation in neurodegenerative diseases
Trends in Cell Biology, 2022Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's disease and several other neurodegenerative disorders. An exciting recent development is the finding that, akin to some other proteins associated with neurodegenerative disease, tau has a high propensity to condensate via the mechanism of liquid-liquid phase ...
Solomiia Boyko, Witold K. Surewicz
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Morphology of Liquid–Liquid Phase Separated Aerosols
Journal of the American Chemical Society, 2015The morphology of liquid-liquid phase separated aerosols has a strong impact on their rate of gas and water uptake, and the type and rate of heterogeneous reactions in the atmosphere. However, it is extremely challenging to experimentally distinguish different morphologies (core-shell or partial wetting) of aerosols and to quantify the extent of ...
Yuqing, Qiu, Valeria, Molinero
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Liquid–liquid phase separation in Alzheimer’s disease
Journal of Molecular MedicineThe pathological aggregation and misfolding of tau and amyloid-β play a key role in Alzheimer's disease (AD). However, the underlying pathological mechanisms remain unclear. Emerging evidences indicate that liquid-liquid phase separation (LLPS) has great impacts on regulating human health and diseases, especially neurodegenerative diseases. A series of
Qinggang Fu +3 more
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Liquid–liquid phase separation in micropores
Current Applied Physics, 2004Phase separation of binary liquids with an upper critical temperature in porous materials is studied by H-1 NMR cryoporometry and cross-relaxation spectroscopy and by N-15 NMR spectroscopy.
Rustem Valiullin +2 more
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Liquid–liquid phase separation in innate immunity
Trends in ImmunologyIntrinsic and innate immune responses are essential lines of defense in the body's constant surveillance of pathogens. The discovery of liquid-liquid phase separation (LLPS) as a key regulator of this primal response to infection brings an updated perspective to our understanding of cellular defense mechanisms. Here, we review the emerging multifaceted
Dawei Liu +2 more
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Liquid–liquid phase separation induced auto-confinement
Soft MatterLiquid-liquid phase separation induced auto-confinement allows macromolecules to attain arrangements typically unachievable through conventional self-assembly processes.
Aoon Rizvi, Joseph P. Patterson
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Liquid–liquid phase separation in cellular signaling systems
Current Opinion in Structural Biology, 2016Liquid-liquid demixing or phase separation of protein with RNA is now recognized to be a key part of the mechanism for assembly of ribonucleoprotein granules. Cellular signaling also appears to employ phase separation as a mechanism for amplification or control of signal transduction both within the cytoplasm and at the membrane.
P Andrew, Chong, Julie D, Forman-Kay
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Liquid–Liquid Phase Separation in Oligomeric Peptide Solutions
Langmuir, 2017Oligomeric peptides exist widely in living organisms and play a role in a broad range of biological functions. We report the first observation of liquid-liquid phase separation (LLPS) in peptide solutions, in particular, solutions of peptides consisting of noncovalent oligomers. We determined the binary phase boundary of the oligomeric peptide solution
Ying Wang +4 more
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