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Applications of Liquid–Liquid Phase Separation in Biosensing
ChemBioChemAbstractPhase separation, particularly liquid‐liquid phase separation (LLPS), has emerged as a powerful tool in biological research, offering unique advantages for visualizing and analyzing biomolecular interactions. This review highlights recent advances in leveraging LLPS to develop experimental techniques for studying protein‐protein interactions ...
Huizhen Huang, Jun Hu
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Liquid–liquid phase separation in cellular signaling systems
Current Opinion in Structural Biology, 2016Liquid-liquid demixing or phase separation of protein with RNA is now recognized to be a key part of the mechanism for assembly of ribonucleoprotein granules. Cellular signaling also appears to employ phase separation as a mechanism for amplification or control of signal transduction both within the cytoplasm and at the membrane.
P Andrew, Chong, Julie D, Forman-Kay
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Comment on “Spontaneous liquid-liquid phase separation of water”
Physical Review E, 2015Yagasaki et al. [Phys. Rev. E 89, 020301 (2014)] present results from a molecular dynamics trajectory illustrating coarsening of ice, which they interpret as evidence of transient coexistence between two distinct supercooled phases of liquid water. We point out that neither two distinct liquids nor criticality are demonstrated in this simulation study.
David T, Limmer, David, Chandler
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The liquid-liquid phase separation in programmed cell death
Cellular SignallingIn recent years, the physical phenomenon of liquid-liquid phase separation has been widely introduced into biological research. Membrane-free organelles have been found to exist in cells that were driven by liquid-liquid phase separation. Intermolecular multivalent interactions can drive liquid-liquid phase separation to form condensates that are ...
Leijing, Yin +3 more
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Protein Folding, Aggregation, and Liquid-Liquid Phase Separation
Current Protein & Peptide ScienceMai, Suan Li, Adam, Liwo, Yuko, Okamoto
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Liquid–liquid phase separation in presynaptic nerve terminals
Trends in Biochemical SciencesThe presynaptic nerve terminal is crucial for transmitting signals to the adjacent cell. To fulfill this role, specific proteins with distinct functions are concentrated in spatially confined areas within the nerve terminals. A recent concept termed liquid-liquid phase separation (LLPS) has provided new insights into how this process may occur. In this
Jiyoung Choi +2 more
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Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
Molecular Cell, 2022Zhijian Chen, Mingjian Du, Yan Fang
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Polyampholyte physics: Liquid–liquid phase separation and biological condensates
Current Opinion in Colloid and Interface Science, 2021Amanda Marciel +2 more
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