Results 91 to 100 of about 5,116,830 (334)

Liquid biopsy: state of reproductive medicine and beyond

, 2021
Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from ...
Coonen, Edith, de Die-Smulders, Christine, Macville, Merryn V E, de Wert, Guido, Paulussen, Aimée D C, van den Wijngaard, Arthur, Schobers, Gaby, Zamani Esteki, Masoud; id_orcid, Brunner, Han G, Koeck, Rebekka, Stevens, Servi J C, Pellaers, Dominique, Macville, M.V.E., Wert, G. de, Stevens, S.J.C., Coonen, E., Brunner, H.G., Pellaers, D., Paulussen, A.D., Die-Smulders, C. de, Esteki, M. Zamani, Wijngaard, A. van den, Schobers, G.M.G., Koeck, R., Merryn V E Macville, Edith Coonen, Masoud Zamani Esteki, Dominique Pellaers, Aimée D C Paulussen, Christine de Die-Smulders, Servi J C Stevens, Arthur van den Wijngaard, Gaby Schobers, Han G Brunner, Rebekka Koeck, Guido de Wert   +35 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The Quest for Non-Invasive Diagnosis: A Review of Liquid Biopsy in Glioblastoma

Cancers
Simple Summary Liquid biopsy is gaining momentum as a non-invasive tool for diagnosing and monitoring the most aggressive brain cancer, glioblastoma (GBM). Unlike brain biopsies, which require invasive surgery, liquid biopsies use biofluids such as blood,
M. Elias, Harry Hadjiyiannis, F. Vafaee, K. Scott, P. de Souza, Therese M. Becker, Shadma Fatima   +6 more
semanticscholar   +1 more source

Current clinically validated applications of liquid biopsy

, 2022
The development of NGS technologies for the study of ctDNA has greatly broadened the possibilities of the clinical application of liquid biopsy (LB). The availability of large gene panels allows obtaining a complete genomic profile of the neoplasm even ...
Incorvaia L., Bazan V., Barraco N., Perez A., La Mantia M., Badalamenti G., Capoluongo E., Rolfo C., Galvano A., Gristina V., Russo A., V. Gristina, N. Barraco, A. Perez, C. Rolfo, E. Capoluongo, A. Galvano, V. Bazan, M. La Mantia, G. Badalamenti, A. Russo, L. Incorvaia   +21 more
core   +1 more source

Advances in liquid biopsy [PDF]

, 2017
Cancer is a lethal disease and ranks as the world’s second most prevalent cause of death. So far, tissue-based biopsy is conducted routinely to detect and monitor the progression of cancer.
Wang, Jenica
core  

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Precision prevention and cancer interception : the new challenges of liquid biopsy

, 2020
: Despite major therapeutic progress, most advanced solid tumors are still incurable. Cancer interception is the active way to combat cancer onset, and development of this approach within high-risk populations seems a logical first step.
Lorente, Jose A., Ruiz-Rodriguez, Antonio J., Carmen Garrido-Navas, Maria, Rolfo, Christian, Malapelle, Umberto, Cardona, Andres F., Pauwels, Patrick, Vilar, Eduardo, Gil-Bazo, Ignacio, Jose Serrano, Maria, Paz-Ares, Luis G., Raez, Luis E., Diaz Mochon, Juan Jose, Russo, Alessandro, Cristofanilli, Massimo, Raez L. E., Garrido-Navas M. C., Pauwels P., Vilar E., Gil-Bazo I., Ruiz-Rodriguez A. J., Cristofanilli M., Lorente J. A., Malapelle U., Mochon J. J. D., Paz-Ares L. G., Rolfo C., Cardona A. F., Serrano M. J., Russo A., Ignacio Gil-Bazo, Luis G. Paz-Ares, Alessandro Russo, Eduardo Vilar, Jose A. Lorente, Andres F. Cardona, Luis E. Raez, Christian Rolfo, Umberto Malapelle, Maria Jose Serrano, Patrick Pauwels, Antonio J. Ruiz-Rodriguez, Juan Jose Diaz Mochon, Massimo Cristofanilli, Maria Carmen Garrido-Navas   +44 more
core   +1 more source

Liquid Biopsy, ctDNA Diagnosis through NGS

, 2021
Liquid biopsy with circulating tumor DNA (ctDNA) profiling by next-generation sequencing holds great promise to revolutionize clinical oncology. It relies on the basis that ctDNA represents the real-time status of the tumor genome which contains ...
Chen Lin, Xuzhu Liu, Chi-Meng Tzeng, Rongqin Ke, Bingyi Zheng   +4 more
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source