Results 71 to 80 of about 5,116,830 (334)

TEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway

Journal of Translational Medicine
Background Mitochondrial transcription elongation factor (TEFM) is a recently discovered factor involved in mitochondrial DNA replication and transcription.
Jia Lei, Qingguo Zhu, Jianghao Guo, Jiaxing Chen, Lixia Qi, Mengmeng Cui, Zhixiong Jiang, Chunhui Fan, Lin Wang, Tianjiao Lai, Yuxi Jin, Lulu Si, Yana Liu, Qi Yang, Dengke Bao, Ruixia Guo   +15 more
doaj   +1 more source

Advanced liquid biopsy technologies for circulating biomarker detection

, 2019
Liquid biopsy is a new diagnostic concept that provides important information for monitoring and identifying tumor genomes in body fluid samples. Detection of tumor origin biomolecules like circulating tumor cells (CTCs), circulating tumor specific ...
Shiddiky, Muhammad JA, Sonar, Prashant, Soda, Narshone, Nam-Trung, Nguyen, Rehm, Bernd HA   +4 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Circulating epithelial cell as viral infection and tissue origin marker in patients with severe COVID-19

The Journal of Liquid Biopsy, 2023
Liquid biopsy (LB) is a minimally invasive procedure that detects biomarkers in body fluids for real-time monitoring of patients. This study developed a new LB approach to analyze Circulating Epithelial Cells (CECs) in Intensive Care Unit (ICU) patients ...
Valeria Denninghoff, María del Carmen Garrido-Navas, María del Pilar Molina-Vallejo, Abel García-Díaz, José Miguel Pérez-Villares, Manuel Colmenero-Ruiz, José Expósito-Hernández, Jose Antonio Lorente, José María Navarro-María, Juan José Díaz-Mochón, Diego de Miguel-Perez, Christian Rolfo, Pedro José Romero-Palacios, Bernardino Alcázar Navarrete, María José Serrano   +14 more
doaj   +1 more source

Review of microRNA detection workflows from liquid biopsy for disease diagnostics

Expert Reviews in Molecular Medicine
MicroRNAs have emerged as effective biomarkers in disease diagnostics, particularly cancer, due to their role as regulatory sequences. More recently, microRNAs have been detected in liquid biopsies, which hold immense potential for early disease ...
Dulguunnaran Naranbat, Emilia Herdes, Nikos Tapinos, Anubhav Tripathi   +3 more
semanticscholar   +1 more source

Liquid biopsy: a review

, 2021
The access to tumor material from a simple blood sample is generally called liquid biopsy. In this review, we describe the needs for such a technique, and the potential applications in oncology.
Steffan A., Brisotto G., Turetta M., Del Ben F., Bulfoni M., Curcio F., Bulfoni, M., Del Ben, F., Turetta, M., Brisotto, G., Curcio, F.   +10 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Transcriptional profiles of circulating tumor cells reflect heterogeneity and treatment resistance in advanced prostate cancer

Journal of Experimental & Clinical Cancer Research
Purpose New biomarkers for the detection and monitoring of aggressive variant prostate cancer (AVPC) including therapy-induced neuroendocrine prostate cancer (NEPC) are urgently needed, as measuring prostate-specific antigen (PSA) is not reliable in ...
Lina Bergmann, Sarah Greimeier, Sabine Riethdorf, Tina Rohlfing, Moritz Kaune, Tobias Busenbender, Nadja Strewinsky, Sergey Dyshlovoy, Simon Joosse, Sven Peine, Klaus Pantel, Gunhild von Amsberg, Stefan Werner   +12 more
doaj   +1 more source

DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers

Cells, 2020
Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile.
Chameera Ekanayake Weeramange, Kai Dun Tang, Sarju Vasani, Julian Langton-Lockton, Liz Kenny, Chamindie Punyadeera   +5 more
doaj   +1 more source

Liquid biopsy testing in urological cancers: Focus on urine.

Urologic oncology
Liquid biopsy has significantly transformed the management of patients with urological cancers. In particular, alternative sources of tumor nucleic acids and analytes beyond blood have taken on a crucial role in these malignancies. In this context, urine
P. Pisapia, F. Pepe, G. Russo, Raffaele Capoluongo, M. Coppola, F. D. Del Giudice, Matteo Ferro, Antonio Madonna, M. Musone, G. Troncone, U. Malapelle, F. Crocetto   +11 more
semanticscholar   +1 more source