Effective osimertinib treatment in a patient with discordant T790 M mutation detection between liquid biopsy and tissue biopsy. [PDF]
, 2018 BACKGROUND:We report the successful treatment of the patient with osimertinib 80 mg/day following disease progression and a discordance in the detection of a mechanism of resistance epithelial growth factor receptor (EGFR) T790 M between liquid biopsy ...
Mambetsariev, Isa +3 more
core +1 more source
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review [PDF]
, 2020 Cell-free DNA profiling using patient blood is emerging as a non-invasive complementary technique for cancer genomic characterization. Since these liquid biopsies will soon be integrated into clinical trial protocols for pediatric cancer treatment ...
Astrahantseff, Kathy +12 more
core +2 more sources
Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]
, 2019 Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J +4 more
core +2 more sources
Clinical application and detection techniques of liquid biopsy in gastric cancer
Molecular Cancer, 2023 Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, and treatment relies on surgical resection or ...
Shuo Ma +8 more
semanticscholar +1 more source
What information could the main actors of liquid biopsy provide? A representative case of non-small cell lung cancer (NSCLC) [PDF]
, 2018 In non-small cell lung cancer (NSCLC), there is a consensus regarding the use of liquid biopsy, generally, to detect "druggable" mutations and, in particular, to monitor tyrosine kinase inhibitor (TKI) treatments. However, whether circulating tumor cells
Manicone, M. +6 more
core +1 more source
Frontiers in Molecular Biosciences, 2021 The high incidence and mortality of lung cancer make early detection of lung cancer particularly important. At present, the diagnosis of lung cancer mainly depends on diagnostic imaging and tissue biopsy. However, current diagnostics are not satisfactory
Lanxiang Huang +11 more
doaj +1 more source
Liquid biopsy epigenomic profiling for cancer subtyping
Nature Network Boston, 2023 In a large multi-cancer cohort, a single liquid biopsy assay enables the detection of four epigenomic modifications, allowing the monitoring of expression of potential drug targets and resistance genes.
S. Baca +42 more
semanticscholar +1 more source
Focused ultrasound-enabled brain tumor liquid biopsy [PDF]
, 2018 Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors.
Chen, Hong +10 more
core +3 more sources
Cell Death and Disease, 2021 TEFM (transcription elongation factor of mitochondria) has been identified as a novel nuclear-encoded transcription elongation factor in the transcription of mitochondrial genome.
Lixin Wan +11 more
doaj +1 more source
Liquid Biopsy for Lung Cancer: Up-to-Date and Perspectives for Screening Programs
International Journal of Molecular Sciences, 2023 Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive approach to determine biomarkers from body fluids, such as blood ...
G. Casagrande +3 more
semanticscholar +1 more source