Results 31 to 40 of about 194,004 (300)

Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β‐catenin signaling

Molecular Oncology, 2020
Tumor‐associated macrophages have important roles in hepatocellular carcinoma (HCC) initiation and progression. Long noncoding RNAs (lncRNAs) have also been reported to be involved in HCC. In this study, we explored how lncRNA LINC00662 may influence HCC
Xiaohui Tian, Yuanyuan Wu, Yating Yang, Jiaxin Wang, Menglan Niu, Shanjun Gao, Tao Qin, Dengke Bao   +7 more
doaj   +1 more source

Transient disappearance of RAS mutant clones in plasma: A counterintuitive clinical use of EGFR inhibitors in RAS mutant metastatic colorectal cancer [PDF]

, 2019
Genomic studies performed through liquid biopsies widely elucidated the evolutionary trajectory of RAS mutant clones under the selective pressure of EGFR inhibitors in patients with wild type RAS primary colorectal tumors. Similarly, the disappearance of
Belardinilli, Francesca, Cortesi, Enrico, Gazzaniga, Paola, Gelibter, ALAIN JONATHAN, Giannini, Giuseppe, Gradilone, Angela, Loreni, Flavia, Mahdavia, Yasaman, Nicolazzo, Chiara, Raimondi, Cristina   +9 more
core   +1 more source

Cost-effectiveness analysis of capecitabine maintenance therapy plus best supportive care vs. best supportive care alone as first-line treatment of newly diagnosed metastatic nasopharyngeal carcinoma

Frontiers in Public Health, 2023
ObjectivesMaintenance therapy with capecitabine after induction chemotherapy for patients with newly diagnosed metastatic nasopharyngeal carcinoma (mNPC) has been confirmed to be effective.
Jiaqi Han, Xiaomeng Lan, Kun Tian, Xi Shen, Jinlan He, Nianyong Chen   +5 more
doaj   +1 more source

Extending colonic mucosal microbiome analysis - Assessment of colonic lavage as a proxy for endoscopic colonic biopsies [PDF]

, 2016
This study was supported through GI Research funds and MRC Grant Ref: MR/M00533X/1 to GH.Peer reviewedPublisher ...
A Durban, A Jain, AC Ouwehand, AD Kostic, AD Kostic, B Willing, CL O’Brien, E Pruesse, EG Zoetendal, EH Simpson, F Backhed, F Chierico Del, G Li, GL Hold, HJ Flint, HL Cash, I Mukhopadhya, I Rangel, J Handelsman, J Jalanka, J Qin, JJ Kozich, JM Choo, JR Marchesi, L Chen, L Drago, L Harrell, M Morotomi, MG Langille, MH McLean, N Segata, NA Kennedy, P Lepage, P Louis, PB Eckburg, PD Schloss, PJ Turnbaugh, R Bibiloni, R Hansen, RE Ley, RL Warren, RM Shobar, S Delgado, SJ Salter, T Vatanen, Team RC, TZ DeSantis, V Mai, Y Momozawa, Y Xie   +49 more
core   +4 more sources

Current Status and Future Perspectives of Liquid Biopsy in Small Cell Lung Cancer

Biomedicines, 2021
Approximately 19% of all cancer-related deaths are due to lung cancer, which is the leading cause of mortality worldwide. Small cell lung cancer (SCLC) affects approximately 15% of patients diagnosed with lung cancer.
Patricia Mondelo-Macía, Jorge García-González, Luis León-Mateos, Adrián Castillo-García, Rafael López-López, Laura Muinelo-Romay, Roberto Díaz-Peña   +6 more
doaj   +1 more source

Evaluation of a novel saliva-based epidermal growth factor receptor mutation detection for lung cancer: A pilot study. [PDF]

, 2016
BackgroundThis article describes a pilot study evaluating a novel liquid biopsy system for non-small cell lung cancer (NSCLC) patients. The electric field-induced release and measurement (EFIRM) method utilizes an electrochemical biosensor for detecting ...
Akin, David, Dong, Gaochao, Dong, Jingsi, Feng, Ziding, Li, Canjun, Li, Yin, Liang, Hao, Pu, Dan, Qiao, Youlin, Qin, Changlong, Qiu, Xiaoming, Sun, Tong, Tang, Xiaojun, Wan, Huajing, Wang, Xi, Wei, Fang, Wong, David TW, Xu, Lin, Yan, QingXiang, Zhang, Wenbiao, Zhen, Yan, Zhou, Qinghua, Zhu, Daxing   +22 more
core   +1 more source

Crucial roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation

Journal for ImmunoTherapy of Cancer, 2022
Cancer-related deaths are mainly caused by metastatic spread of tumor cells from the primary lesion to distant sites via the blood circulation.
Klaus Pantel, Catherine Alix-Panabières
doaj   +1 more source

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative [PDF]

, 2016
Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies.
Aberra, Metasebia, Bender, R. Joseph, Brody, Jonathan, Chung, Vincent, Heartwell, Craig, Hendifar, Andrew, Hoos, William A., Madhavan, Subha, Mason, Kimberly, Matrisian, Lynn M., Mikhail, Sam, Petricoin, Emanuel, III, Picozzi, Vincent, Pishvaian, Michael J., Rahib, Lola, Varieur, Katelyn   +15 more
core   +2 more sources

Mechanobiology and survival strategies of circulating tumor cells: a process towards the invasive and metastatic phenotype

Frontiers in Cell and Developmental Biology, 2023
Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion, intravasation, circulation, arrest/adhesion and extravasation require specific mechanical properties to allow cell survival and the completion of the metastatic ...
Keerthi Kurma, Keerthi Kurma, Keerthi Kurma, Catherine Alix-Panabières, Catherine Alix-Panabières, Catherine Alix-Panabières   +5 more
doaj   +1 more source

The use of heat and chemical penetration enhancers to increase the follicular delivery of erythromycin to the skin [PDF]

, 2019
Copyright © 2019. Published by Elsevier B.V.The effect of heat on the follicular absorption of drugs into the skin has not previously been investigated.
Akomeah, Alberti, Baden, Butcher, Cada, Coldman, Edwards, F. Caserta, FDA, Feldmann, Goh, Higuchi, ICH, Q2(R1), Kim, Kligman, Liu, M.B. Brown, McAuley, McAuley, Minson, Motwani, Motwani, OECD, Oliveira, Otberg, Park, Piazza, Pierard, Rancan, Saar, Santos, Sato, Shergill, Szabo, Teichmann, Toll, Twist, W.J. McAuley, Wood, Wood, Wood, Yarnitsky, Zhang   +42 more
core   +2 more sources