Results 41 to 50 of about 194,004 (300)

Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy

Breast Cancer Research, 2019
Background Breast cancer patients under neoadjuvant chemotherapy includes a heterogeneous group of patients who eventually develop distal disease, not detectable by current methods.
Alba Rodríguez-Martínez, Diego de Miguel-Pérez, Francisco Gabriel Ortega, José Luis García-Puche, Inmaculada Robles-Fernández, José Exposito, Jordi Martorell-Marugan, Pedro Carmona-Sáez, María del Carmen Garrido-Navas, Christian Rolfo, Hugh Ilyine, José Antonio Lorente, Marta Legueren, María José Serrano   +13 more
doaj   +1 more source

Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations

Frontiers in Oncology, 2020
Background: The significance of uncommon epidermal growth factor receptor (EGFR) mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) remains unclear.
Chunhua Ma, Juncheng Zhang, Juncheng Zhang, Dongjiang Tang, Dongjiang Tang, Xin Ye, Xin Ye, Jing Li, Ning Mu, Zhi Li, Renzhong Liu, Liang Xiang, Liang Xiang, Chuoji Huang, Chuoji Huang, Rong Jiang   +15 more
doaj   +1 more source

Circulating Genetically Abnormal Cells Add Non-Invasive Diagnosis Value to Discriminate Lung Cancer in Patients With Pulmonary Nodules ≤10 mm

Frontiers in Oncology, 2021
BackgroundLung cancer screening using low-dose computed tomography (LDCT) often leads to unnecessary biopsy because of the low specificity among patients with pulmonary nodules ≤10 mm.
Maosong Ye, Xiaoxuan Zheng, Xiaoxuan Zheng, Xin Ye, Xin Ye, Xin Ye, Juncheng Zhang, Juncheng Zhang, Chuoji Huang, Chuoji Huang, Zilong Liu, Meng Huang, Meng Huang, Xianjun Fan, Xianjun Fan, Yanci Chen, Yanci Chen, Botao Xiao, Jiayuan Sun, Jiayuan Sun, Chunxue Bai   +20 more
doaj   +1 more source

Similar reduction of cholesterol-adjusted Vitamin E serum levels in simple steatosis and non-alcoholic steatohepatitis [PDF]

, 2015
OBJECTIVES: Reduced vitamin E levels have been reported in patients with non-alcoholic steatohepatitis (NASH), but no conclusive data on patients with simple steatosis (SS) are available. Aim of this study was to investigate the association betweenserum
Angelico, Francesco, Baratta, Francesco, Bucci, Tommaso, Cangemi, Roberto, Carnevale, Roberto, DEL BEN, Maria, Labbadia, Giancarlo, Nocella, Cristina, Pani, Arianna, Pastori, Daniele, Pignatelli, Pasquale, Polimeni, Licia, Scardella, Laura, Violi, Francesco   +13 more
core   +1 more source

Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway

Journal of Translational Medicine
Background Esophageal squamous cell carcinoma (ESCC) ranks among the most prevalent malignancies of the digestive tract. Due to the absence of obvious symptoms in patients with early-stage ESCC, most cases are diagnosed at advanced stages, highlighting ...
Zhixiong Jiang, Yating Yang, Jinchi Zhou, Xin Li, Qingqing Meng, Xiangyi Yu, Yaxin Xue, Mengyu Li, Yichen Cai, Pengchun Han, Mingjun Jiang, Huizhen Wang, Congrong Liu, Jing Zhao, Lixin Wan, Dengke Bao   +15 more
doaj   +1 more source

Circulating epithelial cell as viral infection and tissue origin marker in patients with severe COVID-19

The Journal of Liquid Biopsy, 2023
Liquid biopsy (LB) is a minimally invasive procedure that detects biomarkers in body fluids for real-time monitoring of patients. This study developed a new LB approach to analyze Circulating Epithelial Cells (CECs) in Intensive Care Unit (ICU) patients ...
Valeria Denninghoff, María del Carmen Garrido-Navas, María del Pilar Molina-Vallejo, Abel García-Díaz, José Miguel Pérez-Villares, Manuel Colmenero-Ruiz, José Expósito-Hernández, Jose Antonio Lorente, José María Navarro-María, Juan José Díaz-Mochón, Diego de Miguel-Perez, Christian Rolfo, Pedro José Romero-Palacios, Bernardino Alcázar Navarrete, María José Serrano   +14 more
doaj   +1 more source

Sensitivity of activated human lymphocytes to cyclosporine and its metabolites [PDF]

, 1988
Alloreactive T cells generated as clones from mixed lymphocyte cultures, or propagated from heart or liver transplant biopsies, were tested for secondary proliferation measured in the primed lymphocyte test in the presence of Cyclosporine A and ...
Burckart, G, Duquesnoy, RJ, Makowka, L, Murase, N, Starzl, TE, Van Thiel, DH, Venkataramanan, R, Wang, CP, Zeevi, A   +8 more
core   +1 more source

Targets, pitfalls and reference materials for liquid biopsy tests in cancer diagnostics [PDF]

, 2020
Assessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection, tumor dynamics assessment, minimal residual disease detection and ...
Geeurickx, Edward, Hendrix, An
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation [PDF]

, 2017
The presence of cfDNA in the circulating compartment was demonstrated three decades ago , leading to the emergence of liquid biopsy.However, the implementation of cfDNA methylation as a non-invasive molecular tool for the diagnosis of fibrosis imposes ...
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source