Results 51 to 60 of about 4,935,227 (284)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Regulation of the Liquid–liquid Phase-Separated Droplets of Biomacromolecules by Butterfly-Shaped Gold Nanomaterials [PDF]

, 2022
Liquid–liquid phase-separated (LLPS) droplets play key roles in regulating protein behaviors, such as enzyme compart-mentalization, stress response, and disease pathogenesis, in living cells.
Kentaro, Shiraki, Megumi, Mori, Tatsuya, Murakami, Koji, Takata, Tomohiro, Nobeyama   +4 more
core   +2 more sources

Radionuclide Chemistry in Nuclear Facilities Based on Heavy Liquid Metal Coolants: Past, Present and Future

CHIMIA, 2020
Heavy liquid metals such as lead and lead bismuth eutectic (LBE) are considered as spallation target material for next-generation neutron sources and as coolant of fast spectrum nuclear reactors that are developed to facilitate more efficient use of ...
Jörg Neuhausen
doaj   +1 more source

Application of Liquid Biopsies in Cancer Targeted Therapy [PDF]

Clinical Pharmacology & Therapeutics, 2017
As a growing body of evidence demonstrates intertumoral and intratumoral heterogeneity and clonal evolution, both during carcinogenesis and also throughout treatment resulting in acquired drug resistance, the utility of blood‐based assays or “liquid biopsies” is becoming increasingly recognized in clinical practice and trial design.
Sumanasuriya, S, Lambros, MB, de Bono, JS   +2 more
openaire   +3 more sources

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Experimental Determination of Excitation Function Curves through the Measurement of Thick Target Yields in Liquid Targets: The Examples of the ⁶⁸Zn(p,n)⁶⁸Ga and ⁶⁴Zn(p,α)⁶¹Cu Nuclear Reactions

Instruments, 2022
The present work describes a method to determine excitation function curves and, therefore, cross-sections, making use of the irradiation of liquid targets at distinct energies in a biomedical cyclotron.
Sergio J. C. do Carmo, Francisco Alves
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Using the third state of matter: high harmonic generation from liquid targets

New Journal of Physics, 2014
High harmonic generation on solid and gaseous targets has been proven to be a powerful platform for the generation of attosecond pulses. Here we demonstrate a novel technique for the XUV generation on a smooth liquid surface target in vacuum, which ...
P Heissler, E Lugovoy, R Hörlein, L Waldecker, J Wenz, M Heigoldt, K Khrennikov, S Karsch, F Krausz, B Abel, G D Tsakiris   +10 more
doaj   +1 more source

Revealing the pharmacological effect and mechanism of darutoside on gouty arthritis by liquid chromatography/mass spectrometry and metabolomics

Frontiers in Molecular Biosciences, 2022
Darutoside is a diterpenoids compound with significant anti-inflammatory activity, however the pharmacological action and mechanism are still unclear.
Jing Wang, Yan-Chun Sun, Yan-Chun Sun
doaj   +1 more source