Results 31 to 40 of about 112,596 (251)
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
The New Journalism and the Struggle for Interpretation [PDF]
, 2014 Scholarship in literary journalism often focuses on matters of technique and style, and on the ethical challenges of immersion reporting. In some contexts, however, literary journalism may also take on a sense of moral purpose, as when reporters assert ...
Pauly, John J.
core +2 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The First Baby Born After Polygenic Embryo Screening
Voices in Bioethics, 2022 INTRODUCTION The possibility of using genetic technologies to engineer the perfect baby has long haunted the public imagination. While some techno-utopians have openly advocated for human genetic enhancement, many critics have warned that advances in ...
Kalina Kamenova, Hazar Haidar
doaj
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Human Translation Vs Machine Translation: the Practitioner Phenomenology [PDF]
, 2018 The paper aimed at exploring the current phenomenon regarding human translation with machine translation. Human translation (HT), by definition, is when a human translator—rather than a machine—translate text. It's the oldest form of translation, relying
Xeauyin, L. (Liming), Xiu, P. (Peng)
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
Translation testing and evaluation: A study on methods and needs
Translation and Interpreting : the International Journal of Translation and Interpreting Research, 2014 The use of technology in the translation process has already become a common practice. Translation evaluation in most training programs in Turkey, however, seems to ignore the place of technology since exams are taken using printed resources only.
Mehmet Şahin, Nilgün Dungan
doaj