Results 181 to 190 of about 94,766 (304)

Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines. [PDF]

PLoS Pathog
Lukash T, Poudyal S, Gilliland TC, Klose T, Sun C, Vasilatos SN, Farren JL, Lam LKM, Kuhn RJ, Klimstra WB.   +9 more
europepmc   +1 more source

Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague. [PDF]

mBio, 2021
Kilgore PB, Sha J, Hendrix EK, Motin VL, Chopra AK.   +4 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Benefit risk considerations for African swine fever virus live attenuated vaccines. [PDF]

NPJ Vaccines
Blome S, Friedrichs V, Schäfer A, Beer M.   +3 more
europepmc   +1 more source

Integrating Single‐Cell and Spatial Transcriptomes in HGSOC to Decipher the Metastasis‐Associated Biomarkers

iNew Medicine, EarlyView.
ABSTRACT High‐grade serous ovarian cancer (HGSOC) is the most common and lethal histological subtype of ovarian cancer. This study aimed to identify peritoneal metastasis‐associated biomarkers of HGSOC to provide directions for subsequent treatment. Transcriptome data were extracted from the GEO database and literature. Differential expression analysis,
Jing Zhu, Zhicheng Yu, Yang Zhang, Hui Hong, Xiaoli Wang, Shan Jiang, Ying Zhou, Cheng Peng, Hongbo Chen   +8 more
wiley   +1 more source

Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish. [PDF]

NPJ Vaccines
Porter D, Collins C, Mazzolini A, Jouneau L, Mhanna V, Coiffier C, Peruzzi M, Jaszczyszyn Y, Mariotti-Ferrandiz E, Huetz F, Collet B, Mora T, Walczak AM, Verrier B, Boudinot P.   +14 more
europepmc   +1 more source

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage [PDF]

, 2017
Diamond, Michael S, et al,, Jagger, Brett W, Richner, Justin   +3 more
core   +2 more sources

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

A goatpox but not sheeppox heterologous live attenuated vaccines provide complete protection against lumpy skin disease in cattle under experimental conditions. [PDF]

Sci Rep
Haegeman A, Philips W, Mostin L, De Leeuw I, Van Campe W, Saegerman C, De Clercq K, De Regge N.   +7 more
europepmc   +1 more source