Results 61 to 70 of about 1,768,893 (247)

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Assessment of the variability in influenza A(H1N1) vaccine effectiveness estimates dependent on outcome and methodological approach [PDF]

, 2011
Estimation of Influenza vaccine effectiveness (VE) varies with study design, clinical outcome 10 considered and statistical methodology used. By estimating VE using differing outcomes and 11 statistical methods on the same cohort of individuals the ...
Kavanagh, Kimberley, Robertson, Christopher, McMenamin, Jim   +2 more
core   +5 more sources

Head-to-head comparison of influenza vaccines in children: a systematic review and meta-analysis

Journal of Translational Medicine
Although vaccination is considered the most effective weapon against influenza, coverage rates, national vaccination policies, and funding vary largely around the globe.
Réka Garai, Ágoston Jánosi, Péter Krivácsy, Vivien Herczeg, Tamás Kói, Rita Nagy, Marcell Imrei, Andrea Párniczky, Miklós Garami, Péter Hegyi, Attila József Szabó   +10 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +1 more source

Could Trivalent LAIV Protect Against Both Genetic Lineages of Influenza B Virus?

Vaccine Research, 2019
Introduction: The global co-circulation of two influenza B virus genetic lineages known as B/Yamagata and B/Victoria may lead to a mismatch between the circulating virus and the strain recommended for use in influenza vaccines.
Irina Kiseleva, Ekaterina Stepanova, Elena Krutikova, Svetlana Donina, Andrey Rekstin, Ekaterina Bazhenova, Maria Pisareva, Anastasia Katelnikova, Kirill Kryshen, Arman Muzhikyan, Elena Grigorieva, Larisa Rudenko   +11 more
doaj  

Cross-sectional survey of older people's views related to influenza vaccine uptake [PDF]

, 2006
Background The population's views concerning influenza vaccine are important in maintaining high uptake of a vaccine that is required yearly to be effective.
Hanciles, S, Elizabeth Breeze, Astrid Fletcher, Hanciles, Smita, Breeze, E, Stirling, Sue, Sari Kovats, Fletcher Astrid, Punam Mangtani, Stirling, S, Mangtani, P, Stirling Sue, Fletcher, Astrid, Kovats, Sari, Hanciles Smita, Fletcher, A, Breeze, Elizabeth, Kovats Sari, Mangtani Punam, Kovats, S, Breeze Elizabeth, Sue Stirling, Mangtani, Punam, Smita Hanciles   +23 more
core   +2 more sources

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in England

BMC Medicine, 2017
Background As part of the national seasonal influenza vaccination programme in England and Wales, children receive a quadrivalent vaccine offering protection against two influenza A strains and two influenza B strains.
Dominic Thorrington, Edwin van Leeuwen, Mary Ramsay, Richard Pebody, Marc Baguelin   +4 more
doaj   +1 more source