Results 181 to 190 of about 1,530,452 (285)

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines. [PDF]

PLoS Pathog
Lukash T, Poudyal S, Gilliland TC, Klose T, Sun C, Vasilatos SN, Farren JL, Lam LKM, Kuhn RJ, Klimstra WB.   +9 more
europepmc   +1 more source

Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague. [PDF]

mBio, 2021
Kilgore PB, Sha J, Hendrix EK, Motin VL, Chopra AK.   +4 more
europepmc   +1 more source

Genetic variants of EcPV2 E6 and E7 in equine genital and oronasal squamous cell carcinoma

Equine Veterinary Journal, EarlyView.
Abstract Background Since its discovery in 2008, equine papillomavirus type 2 (EcPV2) has been detected in up to 100% of equine genital and up to 40% of equine oronasal squamous cell carcinomas (SCCs). Preliminary sequence data point to the existence of EcPV2 E6 and E7 oncogene variants compared to the British reference sequence from 2008.
Maya Jenner, Sabine Brandt
wiley   +1 more source

Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish. [PDF]

NPJ Vaccines
Porter D, Collins C, Mazzolini A, Jouneau L, Mhanna V, Coiffier C, Peruzzi M, Jaszczyszyn Y, Mariotti-Ferrandiz E, Huetz F, Collet B, Mora T, Walczak AM, Verrier B, Boudinot P.   +14 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Safety and immunogenicity of live attenuated vaccines during corticosteroid therapy in children with nephrotic syndrome: protocol for an open-label, non-inferiority, randomised controlled trial (VACCINES trial: VAccines in Children on CorticosteroIds for NEphrotic Syndrome). [PDF]

BMJ Open
Mathew G, Madhavan R, Kompithra RZ, Loganathan SK, Abraham AM, Moorthy M, Mammen S, Kannangai R, Samuel P, Verghese VP, Raranveettil D, Agarwal I.   +11 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

A goatpox but not sheeppox heterologous live attenuated vaccines provide complete protection against lumpy skin disease in cattle under experimental conditions. [PDF]

Sci Rep
Haegeman A, Philips W, Mostin L, De Leeuw I, Van Campe W, Saegerman C, De Clercq K, De Regge N.   +7 more
europepmc   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source