Results 51 to 60 of about 1,888,131 (358)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Facilitators and barriers to participation of patients with treatment resistant depression in a randomised controlled trial of two forms of personalised magnetic resonance imaging targeted transcranial magnetic stimulation (the BRIGhTMIND trial)

BMC Psychiatry
Background Magnetic resonance imaging (MRI) can personalise the site of transcranial magnetic stimulation (TMS) delivered as a course of 20 sessions for treatment-resistant depression (TRD). Facilitators and barriers to a randomised controlled trial (RCT)
Clement Boutry, Lucy Webster, Louise Thomson, Delilah Harding, Isabel Reid, Peter Bates, John Gledhill, Rebecca McNaughton, Jane Eastham, Joanne Ooi, Andy Willis, Sonal Marner, Richard Morriss   +12 more
doaj   +1 more source

Mental health outcome measures in the Australian context: what is the problem represented to be?

BMC Psychiatry, 2023
Background There is growing interest in the use of routine outcome measures (ROM) in mental health services worldwide. Australia has been at the forefront of introducing ROM in public mental health services, with the aim of improving services and ...
Candice Oster, Suzanne Dawson, Jocelyn Kernot, Sharon Lawn   +3 more
doaj   +1 more source

Market-induced Asset Specificity: Redefining the Hold-up Problem [PDF]

, 2004
In a standard hold-up problem, individuals are vulnerable to hold-up because it is impossible to write complete contracts to cover the lifespan of relationship-specific investments.
Lewin-Solomons, Shira
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Exploring disparities: a regional analysis of harm reduction supply distribution and opioid-related deaths across Ontario’s Public Health Units

Harm Reduction Journal
Background It is critical that a range of harm reduction supplies are available through Ontario’s Public Health Units (PHU) to meet the varying needs of people who use drugs.
Shaleesa Ledlie, Kristy Scarfone, Dana Shearer, Nadia Zurba, Miroslav Miskovic, Charlotte Munro, Jes Besharah, Shauna Pinkerton, Tyler Watts, Tara Gomes   +9 more
doaj   +1 more source

Psychiatric Inpatients’ Lived Experiences of Physical Restraint: A Qualitative Study in Iran [PDF]

, 2022
Seyyed Taha Yahyavi, Zahra Shahvari
openalex   +1 more source

The Lived Experience of Bipolar Disorder: A Systematic Review and Meta-Synthesis [PDF]

, 2016
The purpose of this meta-synthesis was to review the available qualitative research on the lived experience of persons with bipolar disorder in order to find common themes that may enhance practitioner understanding.
Cooke, Nathan, Corcoran, Jacqueline, Crooks, Paula, Cummings, Cory, Walsh, Joseph   +4 more
core   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source