Results 191 to 200 of about 4,693,650 (362)

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Predicting mortality among patients with liver cirrhosis in electronic health records with machine learning

, 2021
Aixia Guo, Nikhilesh R. Mazumder, Daniela P. Ladner, Randi E. Foraker   +3 more
openalex   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Medical Management of Polycystic Liver Disease: A Position Statement From the European Reference Network on Hepatological Diseases. [PDF]

Liver Int
Heinrich S, de Matos AMC, Colmenero J, Elsharkawy AM, Fraňková S, Halbritter J, Mrzljak A, Müller RU, Pereira R, Strnad P, Teemer CAJ, Verbeek J, Wronka KM, Nevens F, Taubert R, Drenth JPH, European Reference Network on Hepatological Liver Diseases (ERN RARE‐LIVER).   +16 more
europepmc   +1 more source

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

Deuterium Metabolic Imaging of the Human Abdomen at Clinical Field Strength. [PDF]

Invest Radiol
Wodtke P, McLean MA, Horvat-Menih I, Birchall JR, Zamora-Morales MJ, Grimmer A, Latimer E, Wylot M, Schulte RF, Gallagher FA.   +9 more
europepmc   +1 more source

Stable liver graft post anti‐PD1 therapy as a bridge to transplantation in an adolescent with hepatocellular carcinoma

, 2021
Elise Kang, Mercedes Martínez, Hanna Moisander‐Joyce, Yvonne M. Saenger, Adam Griesemer, Tomoaki Kato, Darrell J. Yamashiro, Helen Remotti, Robyn D. Gartrell   +8 more
openalex   +2 more sources

Liver transplantation. [PDF]

Gut, 1968
openaire   +7 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source