Results 11 to 20 of about 12,320,543 (412)
Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]
Frontiers in Medicine, 2020 MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen +4 more
core +2 more sources
Endoplasmic Reticulum Stress in Liver Diseases.
Hepatology, 2022 The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER-resident enzymes and chaperones.
Amir Ajoolabady +6 more
semanticscholar +1 more source
The Nrf2 Pathway in Liver Diseases
Frontiers in Cell and Developmental Biology, 2022 Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol.
Jiaming Zhou, Q. Zheng, Zhi H. Chen
semanticscholar +1 more source
Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis
Periodontology, 2022 The liver carries out a wide range of functions ranging from the control of metabolites, nutrient storage, and detoxification to immunosurveillance. While inflammation is essential for the tissue remodeling and maintenance of homeostasis and normal liver
E. Albuquerque‐Souza, S. E. Sahingur
semanticscholar +1 more source
Oxidative Stress, Genomic Integrity, and Liver Diseases
Molecules, 2022 Excess reactive oxygen species production and free radical formation can lead to oxidative stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the imbalance between ROS production and antioxidants.
Nanthini Sadasivam +3 more
semanticscholar +1 more source
Hepatology, 2020 Alcoholic liver disease (ALD) represents a spectrum of liver injury resulting from alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic hepatitis (AH), alcoholic cirrhosis (AC), and acute alcoholic hepatitis presenting ...
D. Crabb +4 more
semanticscholar +1 more source
Epidemiology of non-alcoholic and alcoholic fatty liver diseases.
Translational Gastroenterology and Hepatology, 2020 Liver diseases are fast emerging as global health priorities. Fatty liver is described in the setting of non-alcoholic fatty liver disease (NAFLD) as well as alcoholic liver disease (ALD), the pathogenesis of excess fat being different in the two ...
Souveek Mitra, Arka De, A. Chowdhury
semanticscholar +1 more source
The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases
Journal of Gastrointestinal Surgery, 2021 Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty (NAFLD) and alcoholic liver disease (ALD). As NAFLD is affecting 10–24% of the general population and approximately 70% of obese patients, it carries a large economic burden ...
Lingxuan An +11 more
semanticscholar +1 more source
Pediatric liver diseases: current challenges and future perspectives [PDF]
, 2015 Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma.
Alisi, Anna +5 more
core +1 more source
Gut microbiome and metabolome signatures in liver cirrhosis-related complications [PDF]
Clinical and Molecular HepatologyBackground/Aims Shifts in the gut microbiota and metabolites are interrelated with liver cirrhosis progression and complications. However, causal relationships have not been evaluated comprehensively.
Satya Priya Sharma +19 more
doaj +1 more source