Results 61 to 70 of about 1,826,226 (307)

A time to act: improving liver health and outcomes in liver disease

, 2009
A report prepared by the British Association for the Study of the Liver (BASL) and the British Society of Gastroenterology (BSG) Liver ...
Sheron, Nick
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Abnormal Liver Enzymes [PDF]

Journal of General Internal Medicine, 2019
John, Bian, Andrew D, Schreiner, Don C, Rockey   +2 more
openaire   +5 more sources

Secretin Inactivating Enzyme in Liver.

Experimental Biology and Medicine, 1962
SummaryThe presence and isolation in a partially purified form of a substance from dog's liver which destroys secretin and has the characteristics of an enzyme are described; it is heat labile, does not dialyze, is most active in pH range 3-5 and shows an initial linear relationship of activity to increasing concentration and incubation time.
Bridgwater, A. B., Kuroyanagi, Y., Chiles, T., Necheles, H.   +3 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device [PDF]

, 2010
Bioartificial Liver Devices (BAL) could provide hepatic function in patients with liver failure awaiting transplantation or liver regeneration. Certain BALs use human hepatoblastoma-derived HepG2 cells that can perform many hepatocyte specific ...
Thomas, A.
core  

A PRELIMINARY EUROPEAN LIVER AND INTESTINE TRANSPLANT ASSOCIATION -EUROPEAN LIVER TRANSPLANT REGISTRY STUDY ON INFORMED RECIPIENT CONSENT AND EXTENDED CRITERIA LIVER DONATION

, 2013
The European Liver and Intestine Transplant Association (ELITA) and the European Liver Transplant Registry (ELTR) coordinated the distribution to European liver transplantation centers of an electronic questionnaire, developed by the first author ...
D. Giannarelli, BRUZZONE, Paolo, the European Liver, the European Liver Transplant Registry, Intestine Transplant Association, R. Adam   +5 more
core   +1 more source

Vitamin C in-vivo Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats

Journal of Applied Sciences and Environmental Management, 2019
This study aimed at assessing the in-vivo effect of Vitamin C on liver enzymes and some endogenous antioxidants in paracetamol-induced model of liver toxicity on Wistar rats.
E.G. Moke, K.K. Anachuna, P.O. Onyilo, M. Emosivbe   +3 more
doaj   +2 more sources

In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin and arjungenin on CYP3A4, CYP2D6 and CYP2C9 enzyme activity in human liver microsomes

Toxicology Reports, 2015
Terminalia arjuna is a tree having an extensive medicinal potential in cardiovascular disorders. Triterpenoids are mainly responsible for cardiovascular properties. Alcoholic and aqueous bark extracts of T.
Alice Varghese, Jay Savai, Nancy Pandita, Ram Gaud   +3 more
doaj   +1 more source