Results 61 to 70 of about 1,119,883 (334)

Issues of intensive care and liver transplantation tactics in fulminant liver failure

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2023
Fulminant liver failure is usually characterized as severe acute liver injury with encephalopathy and synthetic dysfunction (international normalized ratio [INR] ≥1.5) in a patient without cirrhosis or previous liver disease.
L. U. Agumava, V. A. Gulyaev, K. N. Lutsyk, O. D. Olisov, R. B. Akhmetshin, K. M. Magomedov, B. I. Kazymov, A. R. Akhmedov, K. F. Alekberov, B. I. Yaremin, M. S. Novruzbekov   +10 more
doaj   +1 more source

Acute liver failure: A practical update

JHEP Reports
Summary Acute liver failure is a rare and dynamic condition, with a broad aetiology and an incompletely understood pathophysiology. Management of this life-threatening disease requires critical care and organ support and frequently early liver ...
Javier Fernández, O. Bassegoda, David Toapanta, William Bernal   +3 more
semanticscholar   +1 more source

Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review

World Journal of Gastroenterology, 2020
BACKGROUND Acute liver failure (ALF) and acute-on-chronic liver (ACLF) carry high short-term mortality rate, and may result from a wide variety of causes.
E. Tan, Min-Xian Wang, J. Pang, G. Lee
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure

Cells, 2020
Macrophages facilitate essential homeostatic functions e.g., endocytosis, phagocytosis, and signaling during inflammation, and express a variety of scavenger receptors including CD163 and CD206, which are upregulated in response to inflammation.
M. Nielsen, Rasmus Hvidbjerg Gantzel, J. Clària, J. Trebicka, H. Møller, H. Grønbæk   +5 more
semanticscholar   +1 more source

MARS therapy, the bridging to liver retransplantation-Three cases from the Hungarian liver transplant program [PDF]

, 2014
Besides orthotopic liver transplantation (OLT) there is no long-term and effective replacement therapy for severe liver failure. Artificial extracorporeal liver supply devices are able to reduce blood toxin levels, but do not replace any synthetic ...
Bacher A., Ding Y.T., Doros A., Evenepoel P., Gaspari R., Hessel F.P., Kantola T., Kantola T., Karvellas C.J., Liu Y.H., Nemes B., Nemes B., Novelli G., Novelli G., Rademacher S., Rifai K., Schiff E.R., Schuller J., Tan H.K., Wang M.M., Wong F.   +20 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

Toxicological Sciences, 2020
Liver injury and acute liver failure caused by acetaminophen (APAP) overdose is a significant clinical problem in most western countries. The only clinically approved antidote is N-acetylcysteine (NAC), which promotes the recovery of hepatic GSH.
H. Jaeschke, J. Akakpo, David S. Umbaugh, A. Ramachandran   +3 more
semanticscholar   +1 more source

Hepatosplenic sarcoidosis complicated by liver cirrhosis [PDF]

, 2015
Sarcoidosis is a multisystemic disease usually affecting the lungs and mediastinal lymph nodes. Other organs, such as the liver and the spleen, are less commonly involved. Patients usually present with mild nonspecific symptoms.
Bernard, Philippe, Peters, Benjamin, Van Dijck, Herwig, Van Overbeke, Lode, Vanhoenacker, Filip   +4 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source