Results 261 to 270 of about 509,312 (356)

Liver Fibrosis: Interactions Between Cells and Microenvironments. [PDF]

Turk J Gastroenterol
Zou X, Ke Y, Shao Y, Liu S, Shi T.
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Macrophage Nogo-B Drives Liver Fibrosis. [PDF]

Cell Mol Gastroenterol Hepatol
Zhang L, Ni M, Si J, Cheng F, Zhang L, Liang Y, Liu M, Li W, Li J, Chi Y, Rao J, Lu L.   +11 more
europepmc   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

An AI-powered tongue image model for home-based monitoring of liver fibrosis. [PDF]

NPJ Digit Med
Lu XZ, Liu S, Lin XX, Zeng Y, Chen JH, Ke WP, Deng JF, Cheng MQ, Li W, Chen LD, Lu ZK, Sun BG, Hu HT, Wang W.   +13 more
europepmc   +1 more source

Cytochemical Studies on Liver Fibrosis

, 1960
Kaneo Ishii, Hiroshi Suzuki, Michio Ogasawara, Hikaru Koide, Yasuo Endo, Yasuaki Sakata, Takahiro Sakai, Yoshinori Yokono   +7 more
openalex   +2 more sources

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Prognostic Significance of Preoperative Inflammatory and Liver Fibrosis Markers in Hepatocellular Carcinoma. [PDF]

J Inflamm Res
Cheng J, Pan Y, Li X, Lu M, Zhang Y, Wu J, Ye L, Liu X.   +7 more
europepmc   +1 more source

The Cellular Pathways of Liver Fibrosis in NASH

, 2019
Nahúm Méndez‐Sánchez, Carlos E. Coronel-Castillo, Jocelyn Contreras-Carmona, Beatriz Barranco-Fragoso, Xingshun Qi   +4 more
openalex   +2 more sources

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source