Results 41 to 50 of about 2,424,188 (403)
M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]
, 2017 Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li +13 more
core +2 more sources
Cells, 2019 An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological
Giuseppe Mazza +26 more
doaj +1 more source
The role of hepatic microenvironment in hepatic fibrosis development
Annals of Medicine, 2022 Aim Fibrosis is a common pathological feature of most types of chronic liver injuries. There is no specific treatment for liver fibrosis at present. The liver microenvironment, which fosters the survival and activity of liver cells, plays an important ...
Ying Meng +3 more
doaj +1 more source
Hypoxia-induced factor and its role in liver fibrosis [PDF]
PeerJ, 2022 Liver fibrosis develops as a result of severe liver damage and is considered a major clinical concern throughout the world. Many factors are crucial for liver fibrosis progression.
Jan Mohammad Omar, Yang Hai, Shizhu Jin
doaj +2 more sources
Archives of Biochemistry and Biophysics, 2007 NADPH oxidase is a multi-protein complex producing reactive oxygen species (ROS) both in phagocytic cells, being essential in host defense, and in non-phagocytic cells, regulating intracellular signalling. In the liver, NADPH oxidase plays a central role in fibrogenesis.
Samuele De Minicis, David A. Brenner
openaire +3 more sources
Serum hyaluronate as a non-invasive marker of hepatic fibrosis and inflammation in HBeAg-negative chronic hepatitis B [PDF]
, 2005 Background: HBV infection is a serious global heath problem. It is crucial to monitor this disease more closely with a non-invasive marker in clinical trials.
Derakhshan, M.H. +9 more
core +4 more sources
Journal of Diabetes Investigation, 2022 Aims/Introduction To investigate whether the Fibrosis‐4 index can help stratify the risk of diabetes mellitus in patients with fatty liver disease.
Yasuhiko Todo +19 more
doaj +1 more source
Heparanase and macrophage interplay in the onset of liver fibrosis [PDF]
, 2017 The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the ...
Crescenzi, Marika +5 more
core +2 more sources
BMC Medical Imaging, 2021 Background To evaluate different stages of liver fibrosis in cynomolgus monkeys by comparing magnetic resonance-perfusion weighted imaging (MR-PWI) quantitative and semi-quantitative parameters, and confirm the best detection indicators for diagnosis of ...
Ke Ding +7 more
doaj +1 more source
A Prospective Study of Long-term Outcomes in Female Patients with Nonalcoholic Steatohepatitis Using Age- and Body Mass Index-matched Cohorts [PDF]
, 2013 In patients with nonalcoholic steatohepatitis (NASH), the prevalence of cirrhosis is higher among women than men, and hepatocellular carcinoma (HCC) develops mainly in the cirrhotic stage among women.
Hashizume, Hiroaki +5 more
core +1 more source