Results 41 to 50 of about 509,312 (356)
3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model [PDF]
, 2015 Background & Aims Liver biopsy, the gold standard for assessing liver fibrosis, suffers from limitations due to sampling error and invasiveness. There is therefore a critical need for methods to non-invasively quantify fibrosis throughout the entire ...
Caravan, Peter +11 more
core +1 more source
Current Pathobiology Reports, 2015 Hepatocyte death, inflammation, and liver fibrosis are the hallmarks of chronic liver disease. Tumor necrosis factor-α (TNFα) is an inflammatory cytokine involved in liver inflammation and sustained liver inflammation leads to liver fibrosis. TNFα exerts inflammation, proliferation, and apoptosis.
Yang, Yoon Mee, Seki, Ekihiro
openaire +4 more sources
Frontiers in Immunology, 2023 Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation ...
Yufei Liu +6 more
doaj +1 more source
Post hoc analyses of surrogate markers of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis in patients with type 2 diabetes in a digitally supported continuous care intervention: An open-label, non-randomised controlled study [PDF]
, 2018 OBJECTIVE: One year of comprehensive continuous care intervention (CCI) through nutritional ketosis improves glycosylated haemoglobin(HbA1c), body weight and liver enzymes among patients with type 2 diabetes (T2D).
Adams, Rebecca N +10 more
core +2 more sources
Inflammasomes in Liver Fibrosis [PDF]
Seminars in Liver Disease, 2017 AbstractCell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate.
Alegre F, Pelegrin P, Feldstein AE
openaire +4 more sources
Archives of Biochemistry and Biophysics, 2007 NADPH oxidase is a multi-protein complex producing reactive oxygen species (ROS) both in phagocytic cells, being essential in host defense, and in non-phagocytic cells, regulating intracellular signalling. In the liver, NADPH oxidase plays a central role in fibrogenesis.
Samuele, De Minicis, David A, Brenner
openaire +2 more sources
Ultrasound shear wave elastography for liver disease. A critical appraisal of the many actors on the stage [PDF]
, 2016 In the last 12\u200a-\u200a18 months nearly all ultrasound manufacturers have arrived to implement ultrasound shear wave elastography modality in their equipment for the assessment of chronic liver disease; the few remaining players are expected to ...
Cantisani, Vito +4 more
core +1 more source
The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis
Frontiers in Cellular and Infection Microbiology, 2022 Liver fibrosis involves the proliferation and deposition of extracellular matrix on liver tissues owing to various etiologies (including viral, alcohol, immune, and metabolic factors), ultimately leading to structural and functional abnormalities in the ...
Yu-Lin Zhang +14 more
doaj +1 more source
The ability of Hepascore to predict liver fibrosis in chronic liver disease: A meta-analysis [PDF]
, 2016 Background & Aims: Hepascore is a serum model that was developed to assess the severity of liver fibrosis. It has been well validated in common causes of chronic liver disease.
Adams, Leon A. +4 more
core +2 more sources
Canadian Journal of Gastroenterology and Hepatology, 2015 BACKGROUND: Liver disease is the third leading cause of mortality in patients with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD) is challenging.
Matthew D Sadler +5 more
doaj +1 more source