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Frontiers in Immunology, 2023 Liver fibrosis is a global health problem caused by chronic liver injury resulting from various factors. Hepatic stellate cells (HSCs) have been found to play a major role in liver fibrosis, and pathological stimuli lead to their transdifferentiation ...
Yufei Liu +6 more
doaj +1 more source
Timing for treatment of HCV recurrence after liver transplantation: the earlier the better. [PDF]
, 2016 HCV is the leading cause of death from liver disease and is the most common indication for a liver transplantation. Although HCV is a widespread health problem, disease management is particularly challenging in several key subpopulations, including liver
Burra, Patrizia +2 more
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Reversibility of liver fibrosis
Annals of Hepatology, 2009 Liver cirrhosis is a major cause of morbidity and mortality worldwide and has very limited therapeutic options. Regardless of the aetiology, hepatic fibrosis is a characteristic feature of chronic liver disease. Our knowledge regarding the pathogenesis of this scarring has grown exponentially in the past 25 years. It has now clear that this is a highly
John P. Iredale, Prakash Ramachandran
openaire +4 more sources
Liver fibrosis: Pathophysiology and clinical implications
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2020 Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and mortality. The mechanism of fibrosis involves many different cellular pathways, but the major cell type involved appears to be hepatic stellate cells. Many
J. Berumen +3 more
semanticscholar +1 more source
CD4+T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C viruscoinfected patients [PDF]
, 2017 To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients.
Cahn, Pedro +8 more
core +1 more source
Endoglin in liver fibrosis [PDF]
Journal of Cell Communication and Signaling, 2011 Liver fibrosis occurs in most types of chronic liver diseases and is characterized by excessive accumulation of extracellular matrix proteins, leading to disruption of tissue function and eventually organ failure. Transforming growth factor (TGF)-β represents an important pro-fibrogenic factor and aberrant TGF-β action has been implicated in many ...
Anie Philip, Kenneth W. Finnson
openaire +3 more sources
3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model [PDF]
, 2015 Background & Aims Liver biopsy, the gold standard for assessing liver fibrosis, suffers from limitations due to sampling error and invasiveness. There is therefore a critical need for methods to non-invasively quantify fibrosis throughout the entire ...
Caravan, Peter +11 more
core +1 more source
Canadian Journal of Gastroenterology and Hepatology, 2015 BACKGROUND: Liver disease is the third leading cause of mortality in patients with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD) is challenging.
Matthew D Sadler +5 more
doaj +1 more source
The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis
Frontiers in Cellular and Infection Microbiology, 2022 Liver fibrosis involves the proliferation and deposition of extracellular matrix on liver tissues owing to various etiologies (including viral, alcohol, immune, and metabolic factors), ultimately leading to structural and functional abnormalities in the ...
Yu-Lin Zhang +14 more
doaj +1 more source
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis.
New England Journal of MedicineBACKGROUND Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no approved treatment. Resmetirom is an oral, liver-directed, thyroid hormone receptor beta-selective agonist in development for the treatment of NASH with liver fibrosis.
Stephen A. Harrison +28 more
semanticscholar +1 more source