Results 11 to 20 of about 4,185,241 (381)
Hepatic Macrophages in Liver Injury
Frontiers in Immunology, 2020 Ample evidence suggests that hepatic macrophages play key roles in the injury and repair mechanisms during liver disease progression. There are two major populations of hepatic macrophages: the liver resident Kupffer cells and the monocyte-derived ...
Zhao Shan, C. Ju
semanticscholar +4 more sources
Drug-induced liver injury [PDF]
Nature Reviews Disease Primers, 2019 Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use. Drugs can be harmful to the liver in susceptible individuals owing to genetic and environmental risk ...
Raúl J. Andrade +13 more
semanticscholar +7 more sources
International Journal of Molecular Sciences, 2022 Experimental liver injury with hepatocelluar necrosis and abnormal liver tests is caused by exposure to heavy metals (HMs) like aluminum, arsenic, beryllium, cadmium, chromium, cobalt, copper, iron, lead, mercury, molybdenum, nickel, platinum, thallium ...
R. Teschke
semanticscholar +1 more source
BMC Medical Genetics, 2020 Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Current studies have shown that PNPLA3 (Patatin-like phospholipase domain containing 3) rs738409 G/C gene polymorphism is associated ...
Shan Tang +13 more
doaj +1 more source
Cell Death and Disease, 2022 The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains poorly understood. In this study, we demonstrated that the protein expression of GBA1, which catalyses the conversion of GlcCer to ceramide, was downregulated in ...
Zhidong Qiu +11 more
doaj +1 more source
Molecules, 2022 More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive.
Qianru Rao +10 more
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Liver injury during highly pathogenic human coronavirus infections
Liver international (Print), 2020 The severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2), the pathogen of 2019 novel coronavirus disease (COVID‐19), has posed a serious threat to global public health.
Ling Xu +4 more
semanticscholar +1 more source
Metabolic Profile of C-Prenyl Coumarins Using Mass Spectrometry-Based Metabolomics
Molecules, 2021 C-prenyl coumarins (C-PYCs) are compounds with similar structures and various bioactivities, which are widely distributed in medicinal plants. Until now, the metabolic characterizations of C-PYCs and the relationship between metabolism and bioactivities ...
Yan Cheng +5 more
doaj +1 more source
Pathophysiological mechanisms of liver injury in COVID‐19
Liver international (Print), 2020 The recent outbreak of coronavirus disease 2019 (COVID‐19), caused by the Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) has resulted in a world‐wide pandemic.
A. Nardo +5 more
semanticscholar +1 more source