Results 21 to 30 of about 491,812 (319)

Drug-induced liver injury [PDF]

Canadian Medical Association Journal, 2021
Drug-induced liver injury is estimated to have an incidence of 14–19 cases per 100 000 individuals.[1][1],[2][2] Although asymptomatic liver enzyme elevation is the most common presentation, drug-induced liver injury is the most common cause of acute liver failure in most Western countries,
Peter E. Wu, Alexander Kumachev
openaire   +2 more sources

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Nature Communications, 2023
Parabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P.
Qi Zhao, Man-Yun Dai, Ruo-Yue Huang, Jing-Yi Duan, Ting Zhang, Wei-Min Bao, Jing-Yi Zhang, Shao-Qiang Gui, Shu-Min Xia, Cong-Ting Dai, Ying-Mei Tang, Frank J. Gonzalez, Fei Li   +12 more
doaj   +1 more source

Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 −/− mouse model

BMC Microbiology, 2021
Background Emerging evidence implicates the gut microbiome in liver inflammation and hepatocellular carcinoma (HCC) development. We aimed to characterize the temporal evolution of gut dysbiosis, in relation to the phenotype of systemic and hepatic ...
J. Behary, A. E. Raposo, N. M. L. Amorim, H. Zheng, L. Gong, E. McGovern, J. Chen, K. Liu, J. Beretov, C. Theocharous, M. T. Jackson, J. Seet-Lee, G. W. McCaughan, E. M. El-Omar, A. Zekry   +14 more
doaj   +1 more source

Characterization of Frequency-Dependent Material Properties of Human Liver and its Pathologies Using an Impact Hammer [PDF]

Medical Image Analysis, 2011, Vol. 15, No.1, pp. 45-52, 2021
The current methods for characterization of frequency-dependent material properties of human liver are very limited. In fact, there is almost no data available in the literature showing the variation in dynamic elastic modulus of healthy or diseased human liver as a function of excitation frequency.
arxiv   +1 more source

MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell

BMC Cancer, 2022
Background Evidences have indicated that miR-26a-5p regulates the malignant properties of various tumor cells. However, the influences of miR-26a-5p on proliferation, apoptosis and invasion are still vague in the cervical cancer (CC) cells.
Ming Li, Yubo Xiao, Minqi Liu, Qian Ning, Ziye Xiang, Xiang Zheng, Shengsong Tang, Zhongcheng Mo   +7 more
doaj   +1 more source

The liver injuries

Acta chirurgica Iugoslavica, 2010
The liver is the most commonly injured abdominal organ. Severe hepatic trauma continue to be associated with high mortality. Management of liver injuries has changed significantly over the last two decades. Nonoperative management of hemodynamically stable patients has become the first treatment of choice.
Vladimir Djukic, Nenad Ivancevic, Djordje Bajec, Branislav Stefanovic, Kristina Doklestic, Aleksandar Karamarkovic, Nada Popovic, Dejan Radenkovic, Zeljko Lausevic, Pavle Gregoric   +9 more
openaire   +3 more sources

Thiocolchicoside-induced liver injury [PDF]

Clinics, 2011
, but other systemic side effects, such ascardiotoxicity, nephrotoxicity or hepatotoxicity, have notbeen reported. Here, we report the case of a patient whosehepatic and cholestatic enzyme levels were elevated duringthiocolchicoside therapy and returned to normal afterthiocolchicoside was discontinued.
Efe, Cumali, Purnak, Tugrul, Ozaslan, Ersan, Milanlioglu, Aysel   +3 more
openaire   +6 more sources

Poly(γ-glutamic acid)-coated lipoplexes loaded with Doxorubicin for enhancing the antitumor activity against liver tumors

Nanoscale Research Letters, 2017
The study was to develop poly-γ-glutamic acid (γ-PGA)-coated Doxorubicin (Dox) lipoplexes that enhance the antitumor activity against liver tumors. γ-PGA-coated lipoplexes were performed by electrostatistically attracting to the surface of cationic ...
Na Qi, Bo Tang, Guang Liu, Xingsi Liang
doaj   +1 more source

Drug-induced liver injury [PDF]

Nature Reviews Disease Primers, 2019
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use. Drugs can be harmful to the liver in susceptible individuals owing to genetic and environmental risk ...
Neil Kaplowitz, Guruprasad P. Aithal, Harshad Devarbhavi, Paul B. Watkins, Raúl J. Andrade, Michael Merz, Michael Merz, M. Isabel Lucena, Gerd A. Kullak-Ublick, Gerd A. Kullak-Ublick, Einar Bjornsson, Ayako Suzuki, Ayako Suzuki, Naga Chalasani   +13 more
openaire   +5 more sources

Can Viral Load Predict Liver Histology in Patients With Chronic Hepatitis B? [PDF]

International Journal of Travel Medicine and Global Health, 2015
Introduction: Hepatitis B virus (HBV) infection is a global public health problem. Serum HBV DNA measurement is a non-invasive test that predicts the liver disease progression.
Ashraf Karbasi, Behzad Bafandeh, Seyed-Moayed Alavian, Amin Saburi   +3 more
doaj   +1 more source