Results 31 to 40 of about 951,728 (296)

Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 −/− mouse model

BMC Microbiology, 2021
Background Emerging evidence implicates the gut microbiome in liver inflammation and hepatocellular carcinoma (HCC) development. We aimed to characterize the temporal evolution of gut dysbiosis, in relation to the phenotype of systemic and hepatic ...
J. Behary, A. E. Raposo, N. M. L. Amorim, H. Zheng, L. Gong, E. McGovern, J. Chen, K. Liu, J. Beretov, C. Theocharous, M. T. Jackson, J. Seet-Lee, G. W. McCaughan, E. M. El-Omar, A. Zekry   +14 more
doaj   +1 more source

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]

, 2017
Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li, Chen, Yu, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Kong, Ming, Liu, Shuang, Liu, Xin, Lou, Jinli, Pandol, Stephen J, Ren, Feng, Zhang, Xiaohui, Zheng, Qingfen, Zheng, Sujun   +13 more
core   +2 more sources

Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]

, 2015
The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John, Coito, Ana J, Duarte, Sergio, Fujii, Takehiro   +3 more
core   +1 more source

Poly(γ-glutamic acid)-coated lipoplexes loaded with Doxorubicin for enhancing the antitumor activity against liver tumors

Nanoscale Research Letters, 2017
The study was to develop poly-γ-glutamic acid (γ-PGA)-coated Doxorubicin (Dox) lipoplexes that enhance the antitumor activity against liver tumors. γ-PGA-coated lipoplexes were performed by electrostatistically attracting to the surface of cationic ...
Na Qi, Bo Tang, Guang Liu, Xingsi Liang
doaj   +1 more source

MIF contributes to Trypanosoma brucei associated immunopathogenicity development [PDF]

, 2014
African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response, whereby M1-type ...
Beschin, Alain, Brys, Lea, Bucala, Richard, Caljon, Guy, De Baetselier, Patrick, Leng, Lin, Raes, Geert, Sparkes, Amanda, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A, Vansintjan, Liese   +11 more
core   +4 more sources

MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell

BMC Cancer, 2022
Background Evidences have indicated that miR-26a-5p regulates the malignant properties of various tumor cells. However, the influences of miR-26a-5p on proliferation, apoptosis and invasion are still vague in the cervical cancer (CC) cells.
Ming Li, Yubo Xiao, Minqi Liu, Qian Ning, Ziye Xiang, Xiang Zheng, Shengsong Tang, Zhongcheng Mo   +7 more
doaj   +1 more source

Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome [PDF]

, 2016
There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabinoids
Ahmed, Lina, Atkin, Stephen L., Coady, Anne-Marie, Dakroury, Youssra, Elshewehy, Abeer M. M., Kilpatrick, Eric S., Sathyapalan, Thozhukat   +6 more
core   +2 more sources

WSES classification and guidelines for liver trauma [PDF]

, 2016
The severity of liver injuries has been universally classified according to the American Association for the Surgery of Trauma (AAST) grading scale. In determining the optimal treatment strategy, however, the haemodynamic status and associated injuries ...
Abu-Zidan, Fikri M., Ansaloni, Luca, Biffl, Walter, Catena, Fausto, Ceresoli, Marco, Coccolini, Federico, Coimbra, Raul, Fraga, Gustavo, Ivatury, Rao, Kluger, Yoram, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Peitzman, Andrew, Rizoli, Sandro, Sartelli, Massimo, Weber, Dieter, Zanini, Nicola   +18 more
core   +2 more sources

Mechanism and suggestions of liver damage caused by influenza A virus: a narrative review [PDF]

Infectious Diseases and Tropical Medicine
This study aimed to explore the causes and mechanisms of liver damage caused by influenza A virus (IAV), compare the liver damage caused by SARS-CoV-2 and IAV under China’s Glasnost, propose treatment and vaccination recommendations for IAV, and provide ...
Y. Yin, R. Luo, S. Li, R. Li
doaj   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source