Results 31 to 40 of about 491,812 (319)

Association between vessels that encapsulate tumour clusters vascular pattern and hepatocellular carcinoma recurrence following liver transplantation

Frontiers in Oncology, 2022
BackgroundVessels that encapsulate tumor clusters (VETC) is a novel vascular pattern seen on hepatocellular carcinoma (HCC) histology which has been shown to independently predict tumor recurrence and survival after liver resection.
Claude Dennis, David S. Prince, David S. Prince, Leila Moayed-Alaei, Devika Remash, Emily Carr-Boyd, David G. Bowen, David G. Bowen, Simone I. Strasser, Simone I. Strasser, Michael Crawford, Carlo Pulitano, Carlo Pulitano, James Kench, James Kench, Geoffrey W. McCaughan, Geoffrey W. McCaughan, Geoffrey W. McCaughan, Catriona McKenzie, Catriona McKenzie, Ken Liu, Ken Liu, Ken Liu   +22 more
doaj   +1 more source

Mechanism and suggestions of liver damage caused by influenza A virus: a narrative review [PDF]

Infectious Diseases and Tropical Medicine
This study aimed to explore the causes and mechanisms of liver damage caused by influenza A virus (IAV), compare the liver damage caused by SARS-CoV-2 and IAV under China’s Glasnost, propose treatment and vaccination recommendations for IAV, and provide ...
Y. Yin, R. Luo, S. Li, R. Li
doaj   +1 more source

Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review

Frontiers in Pharmacology, 2022
Isoniazid (INH) and rifampicin (RFP) are the first-line medications for tuberculosis treatment, and liver injury is the major adverse effect. Natural medicinal ingredients provide distinct benefits in alleviating patients’ symptoms, lowering the liver ...
Xiuping Zhuang, Xiuping Zhuang, Li Li, Tianyi Liu, Rui Zhang, Peimin Yang, Xin Wang, Long Dai   +7 more
doaj   +1 more source

Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response [PDF]

J. Phys. Chem. B 116, 4457-4464 (2012), 2013
We report the first realization of a biomolecular AND gate function with double-sigmoid response (sigmoid in both inputs). Two enzyme biomarker inputs activate the gate output signal which can then be used as indicating liver injury, but only when both of these inputs have elevated pathophysiological concentrations, effectively corresponding to logic-1
arxiv   +1 more source

Hypoxic Liver Injury [PDF]

Mayo Clinic Proceedings, 2006
Hypoxic liver injury is defined as a massive, but transient, increase in serum transaminase levels due to an imbalance between hepatic oxygen supply and demand in the absence of other acute causes of liver damage. It typically occurs in elderly individuals with right-sided congestive heart failure and low cardiac output.
openaire   +3 more sources

Role of liver progenitors in acute liver injury [PDF]

Frontiers in Physiology, 2013
Acute liver failure (ALF) results from the acute and rapid loss of hepatocyte function and frequently exhibits a fulminant course, characterized by high mortality in the absence of immediate state-of-the-art intensive care and/or emergency liver transplantation (ELT).
Jan eBest, Jan eBest, Laurent eDollé, Paul eManka, Jason eCoombes, Leo A. van Grunsven, Wing-Kin eSyn   +6 more
openaire   +5 more sources

A case of Beauveria bassiana keratitis confirmed by internal transcribed spacer and LSU rDNA D1–D2 sequencing

New Microbes and New Infections, EarlyView., 2014
Abstract We describe a case of fungal keratitis due to Beauveria bassiana in a farmer with Fuchs' dystrophy, treated with amphotericin B. Surgery with penetrating keratoplasty was necessary to resolve the lesions. Susceptibility testing and molecular sequencing permitted the identification and treatment of this rare aetiological agent of invasive ...
M. Ligozzi, L. Maccacaro, M. Passilongo, E. Pedrotti, G. Marchini, R. Koncan, G. Cornaglia, A. R. Centonze, G. Lo Cascio   +8 more
wiley   +1 more source

Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda

International Journal of Hepatology, 2023
Introduction. The evaluation of the patterns of liver injury, derived from liver chemistry panels, often may narrow on probable causes of the liver insult especially when coupled with clinical history, examination, and other diagnostic tests.
Clara Wekesa, Rosalind Parkes-Ratanshi, Gregory D. Kirk, Ponsiano Ocama   +3 more
doaj   +1 more source

Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury [PDF]

arXiv, 2023
During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the liver. Our recent study has shown a correlation between the bile-to-plasma ratio of FDA-approved sodium fluorescein (SF)
arxiv  

A Biochemical Logic Approach to Biomarker-Activated Drug Release [PDF]

J. Mater. Chem. 22, 19709-19717 (2012), 2013
The present study aims at integrating drug-releasing materials with signal-processing biocomputing systems. Enzymes alanine transaminase (ALT) and aspartate transaminase (AST)---biomarkers for liver injury---were logically processed by a biocatalytic cascade realizing Boolean AND gate. Citrate produced in the system was used to trigger a drug-mimicking
arxiv   +1 more source