Results 71 to 80 of about 945,580 (358)

Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis

Journal of Physiological Sciences
The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups.
Xiaomin Hong, Sanqiang Li, Renli Luo, Mengli Yang, Junfei Wu, Shuning Chen, Siyu Zhu   +6 more
doaj   +1 more source

Heparanase and macrophage interplay in the onset of liver fibrosis [PDF]

, 2017
The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the ...
Crescenzi, Marika, Floreani, Annarosa, Masola, Valentina, Onisto, Maurizio, Russo, Francesco Paolo, Secchi, Maria Francesca   +5 more
core   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2

Experimental and Molecular Medicine
Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-
Wei Dong, Qing Li, Xing Lu, Jianfeng Lan, Zhidong Qiu, Xuehong Wang, Junnan Wang, Xiaojiao Zheng, Sifan Chen, Chong Zhang, Junfei Jin   +10 more
doaj   +1 more source

LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway

Acta Biochimica et Biophysica Sinica, 2022
Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis. If the injury persists, liver injury can lead to cirrhosis and liver failure and ultimately results in the development of liver cancer.
Shao Shuai, Zhang Yu, Zhou Feng, Meng Xiaoxiang, Yu Zhenjun, Li Guantong, Zheng Lina, Zhang Kun, Li Yuhan, Guo Beichen, Liu Qi, Zhang Mengxia, Du Xiaoxiao, Hong Wei, Han Tao   +14 more
doaj   +1 more source

Lamivudine-Induced Liver Injury

Open Access Macedonian Journal of Medical Sciences, 2015
BACKGROUND: Lamivudine is a nucleoside analogue antiretroviral drug, known for its low toxicity at clinically prescribed dose. However, the toxicity or mechanism of toxicity and target tissue effects during prolonged administration of higher doses were hardly given sufficient laboratory attention.AIM: The present work was designed to investigate the ...
Olaniyan, Lamidi W. B., Maduagwu, E. N., Akintunde, Olalekan Wasiu, Oluwayelu, Oladimeji O., Brai, Bartholomew I. C.   +4 more
openaire   +6 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Relationship between Obstructive Sleep Apnea and Liver Abnormalities in Older Patients: A Cross-Sectional Study

International Journal of Clinical Practice, 2023
Background. Older age is a risk factor for obstructive sleep apnea (OSA), which is associated with the development of nonalcoholic fatty liver disease (NAFLD).
Yong-Xu Jin, Bi-ying Wang, Xiao-li Wang, Xing Yu, Li-da Chen, Yi-song Yang, Jie-feng Huang   +6 more
doaj   +1 more source

Drug-induced liver injury [PDF]

Clinical Medicine, 2016
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the clinical setting is idiosyncratic in nature because affected individuals represent only a small proportion of those treated with such drugs. In many cases, the mechanism for
Dev Katarey, Sumita Verma
openaire   +4 more sources

Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury [PDF]

, 2017
Purpose. To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI). Materials and Methods.
Gorgey, Ashraf S., Khan, M. Rehan, O’Brien, Laura C., Rankin, Kathleen C., Segal, Liron   +4 more
core   +3 more sources