Results 131 to 140 of about 2,360,733 (398)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oligometastases in pancreatic cancer (Synchronous resections of hepatic oligometastatic pancreatic cancer: Disputing a principle in a time of safe pancreatic operations in a retrospective multicenter analysis)

Annals of Gastroenterological Surgery, 2019
The aim of the present review was to analyze the current data on surgery of synchronous liver metastases in pancreatic ductal adenocarcinoma (PDAC) in curative intent.
Nina Voss, Jakob R. Izbicki, Michael F. Nentwich   +2 more
doaj   +1 more source

Pathology of Liver Metastases

Cancer Control, 2006
The liver is the most frequent site of metastatic disease, and metastatic disease to the liver is far more common than primary liver carcinoma in the United States. Pathologic evaluation of biopsy samples is key to establishing a correct diagnosis for patient management.
openaire   +2 more sources

Systematic review of liver directed therapy for uveal melanoma hepatic metastases.

HPB, 2019
BACKGROUND Uveal melanoma (UM) is a rare malignancy with a propensity for metastasis to the liver. Systemic chemotherapy is typically ineffective in these patients with liver metastases and overall survival is poor. There are no evidence-based guidelines
A. Rowcroft, B. Loveday, B. Thomson, S. Banting, B. Knowles   +4 more
semanticscholar   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Processing-independent assay of serum gastrin for diagnosis of liver metastases in the Zollinger-Ellison syndrome [PDF]

, 1997
Philippe Jaïs, M Mignon, Jens F. Rehfeld   +2 more
openalex   +1 more source

Supplemental Figure 3 from Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor–Modified T-cell Therapy for CEA⁺ Liver Metastases

, 2023
Steven C. Katz, Rachel A. Burga, Elise McCormack, Lijuan Wang, Wesley Mooring, Gary R. Point, Pranay D. Khare, Mitchell Thorn, Qiangzhong Ma, Brian F. Stainken, Earle O. Assanah, Robin Davies, N. Joseph Espat, Richard P. Junghans   +13 more
openalex   +1 more source

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

Nature Medicine, 2016
The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of through the induction of angiogenesis, tumor vascularization can occur through the nonangiogenic mechanism of vessel co ...
Sophia Frentzas, È. Simoneau, Victoria Bridgeman, P. Vermeulen, S. Foo, Eleftherios Kostaras, M. Nathan, A. Wotherspoon, Zu-hua Gao, Yu Shi, G. G. Van den Eynden, F. Daley, C. Peckitt, X. Tan, A. Salman, A. Lazaris, P. Gazinska, Tracy J. Berg, Z. Eltahir, L. Ritsma, J. van Rheenen, A. Khashper, G. Brown, H. Nyström, M. Sund, S. V. van Laere, E. Loyer, L. Dirix, D. Cunningham, P. Metrakos, Andrew R Reynolds   +30 more
semanticscholar   +1 more source