Results 41 to 50 of about 1,127,916 (265)

Complete remission of multiple liver metastases with only partial response of the primary rectal cancer after neoadjuvant chemotherapy

Surgical Case Reports, 2020
Background Colorectal cancer is commonly diagnosed among the Japanese population, and various strategies in treating the colorectal liver metastasis have been introduced over the years.
Satomi Miura, Kyoji Ito, Nobuyuki Takemura, Fuminori Mihara, Tomomichi Kiyomatsu, Norihiro Kokudo   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Radioembolization treatment for liver metastases

, 2017
The liver is an organ that, due to vascularisation and functions, is prone to metastases. Most liver metastases are observed in cases of gastrointestinal cancers in: stomach, colon, gallbladder, and bile ducts.
Joanna Kiszka, Bożenna Karczmarek-Borowska   +1 more
core   +1 more source

Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial [PDF]

, 2018
BACKGROUND: Although surgical resection has been considered the only curative option for colorectal liver metastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment.
van Laarhoven, C. J. H. M., Stephen Morris, Twiddy, M, Croft, Julie, de Wilt, Johannes H. W., Gurusamy, Kurinchi, Damink, Steven Olde; id_orcid, C. J. H. M. van Laarhoven, Kurinchi Gurusamy, Steve Bandula, Prasad, R, Brian R. Davidson, Neil Corrigan, Gurusamy, K, Morris, Stephen, Hochhauser, Daniel, Jakowiw, Nicholas, Twiddy, Maureen, Damink, SO, Laarhoven, C.J.H.M. van, Davidson, BR, Nick Woodward, de Wilt, JHW, Corrigan, Neil, Croft, J, Jakowiw, N, Wilt, J.H.W. de, Brown, J, Hochhauser, D, Daniel Hochhauser, Woodward, N, Alison Pullan, Davidson, B.R., Maureen Twiddy, Raj Prasad, Corrigan, N, Woodward, Nick, Davidson, Brian R., Julie Croft, Bandula, S, Bandula, Steve, Steven Olde Damink, Gurusamy, K., Napp, V, de Wilt, Johannes H.W., Napp, Vicky, van Laarhoven, CJHM, Brown, Julia, Nicholas Jakowiw, Prasad, Raj, van Laarhoven, C. J.H.M., Morris, S, Johannes H. W. de Wilt, Damink, Steven Olde, Pullan, A, Pullan, Alison, Julia Brown, Vicky Napp, Morris, S.   +58 more
core   +2 more sources

Treatment strategies for neuroendocrine liver metastases: a systematic review. [PDF]

, 2022
BACKGROUND Gastroenteropancreatic neuroendocrine tumors are often diagnosed when metastatic. The liver is the main site of metastases. Unfortunately, optimal management of neuroendocrine liver metastases remains a topic of debate.
Pessaux, Patrick, Rossi, Stefano, Felli, Eric, Muttillo, Irnerio Angelo, Muttillo, Irnerio A, Felli, Emanuele, Picardi, Biagio, Muttillo, Edoardo Maria, Baiocchini, Andrea, Diana, Michele, Cinelli, Lorenzo, Muttillo, Edoardo M, Mazzarella, Gennaro   +12 more
core   +1 more source

A novel patient-derived organoids-based xenografts model for preclinical drug response testing in patients with colorectal liver metastases

Journal of Translational Medicine, 2020
Backgrounds Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of colorectal liver metastases (CLMs).
Mi Jian, Li Ren, Guodong He, Qi Lin, Wentao Tang, Yijiao Chen, Jingwen Chen, Tianyu Liu, Meiling Ji, Ye Wei, Wenju Chang, Jianmin Xu   +11 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Recommendations for management of patients with neuroendocrine liver metastases

, 2014
Many management strategies exist for neuroendocrine liver metastases. These strategies range from surgery to ablation with various interventional radiology procedures, and include both regional and systemic therapy with diverse biological, cytotoxic, or ...
Caplin, Martyn, G. Grazi, Dik Kwekkeboom, Russell, Christopher, de Herder, W.W., Stefan Breitenstein, Catherine Klersy, Martyn Caplin, for the Working Group on Neuroendocrine Liver Metastases, Breitenstein, S, Schilsky, Richard, Irvin M. Modlin, Solcia, Enrico, Klersy, C, Russell, C, Siegler, M, Enrico Solcia, Mark Siegler, Kidd, M, Richard Schilsky, Schilsky, R, Lau, Wan-yee, Kwekkeboom, Dik, Andrea Frilling, Frilling, Andrea, Caplin, M, Salem, Riad, Wan-yee Lau, Klersy, Catherine, Davidson, B, Christopher Russell, Kidd, Mark, ), Vilgrain, Valerie, Davidson, Brian, Valerie Vilgrain, Modlin, IM, Modlin, Irvin M, Frilling, A, Solcia, E, Salem, R, Lau, WY, Vilgrain, V, Riad Salem, Siegler, Mark, Breitenstein, Stefan, Mark Kidd, Brian Davidson   +47 more
core   +1 more source

Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies

Molecular Cancer
Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout the process of liver metastases formation, immune cells play a pivotal role, particularly in the pre ...
Chang Zhu, Jing-Yu Liao, Yi-Yang Liu, Ze-Yu Chen, Rui-Zhi Chang, Xiao-Ping Chen, Bi-Xiang Zhang, Jun-Nan Liang   +7 more
doaj   +1 more source