Results 121 to 130 of about 27,503 (167)

Phosphatidylcholine mobility in liver microsomal membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1978
Purified phosphatidylcholine exchange protein from bovine liver was used to exchange rat liver microsomal phosphatidylcholine for egg phosphatidylcholine. It was found that at 25 and 37 degrees C rat liver microsomal phosphatidylcholine was completely and rapidly available for replacement by egg phosphatidylcholine.
A M, van den Besselaar, B, de Druijff, H, van den Bosch, L L, van Deenen   +3 more
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Reversible inactivation of liver microsomal pyrophosphatese

Life Sciences, 1972
Abstract Rat liver microsomes lost their pyrophosphatase activity in a pH and temperature dependent reaction. Peroxidation of microsomal lipids did not appear to be required as inactivation occured in the absence of measurable lipid peroxidation. The pH of the media affected the final extent of enzyme inactivation.
G W, Rafter, B H, Witherspoon
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Gliclazide hydroxylation by rat liver microsomes

Xenobiotica, 1995
1. The metabolism of gliclazide to hydroxygliclazide has been investigated in Sprague-Dawley rat liver microsomes. 2. The kinetics of hydroxygliclazide formation are consistent with Michaelis-Menten kinetics (mean (+/- SD, n = 3) apparent K(m) and Vmax = 256 +/- 27 microM and 1.85 +/- 0.10 nmol/ min/mg respectively). 3.
A, Rieutord, I, Stupans, G M, Shenfield, A S, Gross   +3 more
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Interaction of ranitidine with liver microsomes

Xenobiotica, 1982
1. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić, T, Alebić-Kolbah, F, Kajfez, H H, Ruf   +3 more
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Microsomal monooxygenase system in frog livers

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1984
Liver microsomes prepared from four species of frog, Rana catesbeiana, Rana nigromaculata , Bufo bufo japonicus, and Xenopus laevis, contained cytochrome P-450 and showed NAD(P)H-dependent monooxygenase activities to several foreign chemical compounds tested.
M, Noshiro, T, Omura
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Benzene metabolism in mouse liver microsomes

Toxicology and Applied Pharmacology, 1973
Abstract Mouse liver microsomes metabolized benzene more rapidly than microsomes prepared from rat and rabbit liver. Treatment of mice with benzene increased the metabolism of benzene in vitro without increasing cytochrome P-450 concentrations. Conversely, treatment of mice with phenobarbital increased cytochrome P-450 values but did not increase ...
L M, Gonasun, C, Witmer, J J, Kocsis, R, Snyder   +3 more
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Metabolism of nitrosoacetoxymethylmethylamine in liver microsomes

Biochemical Pharmacology, 1981
Abstract The carcinogen nitrosoacetoxymethylmethylamine (NAMM)‡ was incubated with mouse liver microsomes. The decomposition rate of NAMM and the formation of methanol were determined. After addition of an NADPH-regenerating system, formaldehyde formation resulting from metabolic degradation of the methyl group of NAMM was measured.
K E, Appel, N, Frank, M, Wiessler
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Interaction of Cimetidine with Liver Microsomes

Xenobiotica, 1979
1. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić, V, Sunjić, R, Toso, F, Kajfez, H H, Ruf   +4 more
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Permeability of Liver Microsomal Membranes to Glucose

Biochemical and Biophysical Research Communications, 1996
The permeability of rat liver microsomes to glucose has been studied by using (14)C-labelled D-glucose and a light-scattering technique. 1) The microsomal intravesicular apparent isotope space for D-glucose (1mM; after 5 min incubation at 22 degrees C) was 2.34 microl/mg protein, i.e., approximately 72% of the apparent water space.
MARCOLONGO, P., FULCERI, R., GIUNTI, R., BURCHELL, A., BENEDETTI, A.   +4 more
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Fumonisin B1 Metabolism by Bovine Liver Microsomes

Veterinary Research Communications, 2001
Only limited and contrasting information is available about the metabolic fate in cattle of fumonisin B1, a mycotoxin produced by moulds of Fusarium. This study was carried out to evaluate the hepatic metabolism of fumonisin B1 by bovine liver microsomes.
M. SPOTTI, G. POMPA, F. CALONI
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