Results 191 to 200 of about 1,906,831 (271)

EFFECT OF STARVATION ON NADPH-DEPENDENT ENZYMES IN LIVER MICROSOMES OF MALE AND FEMALE RATS

Journal of Pharmacology and Experimental Therapeutics, 1965
Although liver microsomes from male rats metabolize most drugs more rapidly than do those from female rats, the magnitude of the sex difference varies markedly with the substrate.
R. Kato, J. Gillette
semanticscholar   +1 more source

Pigments of rat liver microsomes

Archives of Biochemistry and Biophysics, 1958
Abstract The total hemin content of washed rat liver microsomes is 2.15 times the cytochrome b5 content, only a small part being due to bound hemoglobin. The content of flavine is 4 5 that of cytochrome b5. The flavine probably does not contribute to the DPNH reduced difference spectrum.
openaire   +3 more sources

Ethylene Formation in Rat Liver Microsomes

Science, 1966
Reduced triphosphopyridine nucleotide and pyrophosphate-dependent peroxidation of lipids in rat liver microsomes were coupled to the generation of ethylene in the presence of cuprous ions. This system suggests a model for the biogenesis of ethylene in cells.
M, Lieberman, P, Hochstein
openaire   +2 more sources

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Drug Metabolism And Disposition, 1990
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P-450IIIA. We therefore anticipated that any drug that is an inducer or an inhibitor of this cytochrome should lead to ...
L. Pichard, I. Fabre, G. Fabre, J. Domergue, B. Aubert, G. Mourad, P. Maurel   +6 more
semanticscholar   +1 more source

Metabolism of naphthalene by pigeon liver microsomes

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1979
Abstract 1. Microsomal mixed-function oxidase of the pigeon liver shows maximum activity and stability at 44°C and 6.8 pH. Naphthalene is metabolized to 1-naphthol and 1,2-diol and a number of minor metabolites. The MFO activity and P-450 contents of pigeon liver microsomes, under optimum conditions show about 1 3 to 1 4 activity of ...
J C, Grossman, M A, Khan
openaire   +2 more sources

Development of Liver Microsomal Oxidations in the Chick

Xenobiotica, 1976
1. Liver microsomal preparations from chick embryos (1 day before hatching) and from 1-7 day old chicks were assayed for oxidative drug-metabolizing activity with aminopyrine, aniline and naphthalene as substrates. 2. Activities for all three substrates were highest in preparations from 1 day-old chicks.
G, Powis, A H, Drummond, D E, Macintyre, W R, Jondorf   +3 more
openaire   +2 more sources

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

Journal of Pharmacology and Experimental Therapeutics, 1996
Cytochrome P450 chemical inhibitors are widely used to define the role of individual cytochrome P450 isozyme(s) in a metabolism process. In this study, cytochrome P450 isoform-dependent reactions were investigated on our human liver microsomes bank (n ...
M. Bourrié, V. Meunier, Y. Berger, G. Fabre   +3 more
semanticscholar   +1 more source

Microsomal antigens in developing chick liver

Experimental Cell Research, 1965
Abstract Microsomes from embryonic and adult chick liver have been analyzed by homologous antisera. The deoxycholate-soluble fraction of embryonic microsomes contains a group of antigens typical to this fraction, but present only as a trace in the adult-homologous fraction.
V, MUTOLO, V, D AMELIO, E, PIAZZA
openaire   +2 more sources

In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

Drug Metabolism And Disposition, 2000
The UDP-glucuronosyltransferases (UGTs) are a superfamily of membrane-bound enzymes whose active site is localized inside the endoplasmic reticulum.
M. Fisher, K. Campanale, B. Ackermann, M. Vandenbranden, S. Wrighton   +4 more
semanticscholar   +1 more source

A microsomal exoribonuclease from rat liver

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
A exoribonuclease has been purified from the microsomes of rat liver. The enzyme had an apparent molecular weight of 80 000-83 000 and produced, via a processive mechanism, 5'-AMP as the only product from poly(A). The degradation was found to proceed in the 3' to 5' direction.
H, Kumagai, K, Igarashi, K, Tanaka, H, Nakao, S, Hirose   +4 more
openaire   +2 more sources