Results 201 to 210 of about 1,906,831 (271)

Chromate metabolism in liver microsomes

Biological Trace Element Research, 1979
The carcinogenicity and mutagenicity of various chromium compounds have been found to be markedly dependent on the oxidation state of the metal. The carcinogen chromate was reduced to chromium(III) by rat liver microsomes in vitro. Metabolism of chromate by microsomal enzymes occurred only in the presence of either NADPH or NADH as cofactor.
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The interaction of cimetidine with rat liver microsomes

Biochemical Pharmacology, 1983
The binding of cimetidine to rat liver microsomes in M/15 phosphate buffer, pH 7.9, has been investigated by difference spectroscopy and also by equilibrium partition studies, the latter method providing the more definitive characterization of the interaction in the pharmacologically relevant, low micromolar range of drug concn. In addition, the effect
Reilly P.E.B., Carrington L.E., Winzor D.J.   +2 more
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Esterification of cholesterol in rat liver microsomes

Archives of Biochemistry and Biophysics, 1964
Washed rat liver microsomes esterify cholesterol in the presence of added ATP and CoA; net synthesis of cholesterol esters was demonstrated. The optimum pH of the reaction was between 6.8 and 7.2; the effects of time and concentration of substrate were investigated.
L, SWELL, M D, LAW, C R, TREADWELL
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Metabolism of doxophylline by rat liver microsomes.

Drug Metabolism and Disposition, 1986
The metabolic transformation of the bronchospasmolytic agent doxophylline (2-(7'-theophyllinemethyl)-1,3-dioxolane) was studied in vitro with phenobarbital-induced rat liver microsomal fraction containing the NADPH-generating system. Doxophylline was poorly metabolized as 95% of the recovered material was parent compound. The major metabolite resulted:
GROSA, Giorgio, J. S. FRANZONE, G. BIGLINO   +2 more
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Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

Journal of Pharmacology and Experimental Therapeutics, 2001
Interindividual variability in acetaminophen (APAP) glucuronidation may contribute to differences in susceptibility to APAP intoxication in humans.
M. Court, S. Duan, L. Moltke, D. Greenblatt, C. Patten, J. Miners, P. Mackenzie   +6 more
semanticscholar   +1 more source

Metabolism of Dietary Flavonoids in Liver Microsomes

Current Drug Metabolism, 2013
Flavonoids undergo substantial hepatic metabolism and the metabolites might significantly contribute to the effects of these dietary constituents. The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4'-, C-3', C-6 and C-8- position when there is a single or no hydroxy group ...
Jianbo, Xiao, Petra, Högger
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Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

Journal of Pharmacology and Experimental Therapeutics, 1996
The HIV-1 protease inhibitor ritonavir (ABT-538) undergoes cytochrome P450-mediated biotransformation in human liver microsomes to three major metabolites, Ml, M2 and M11, with wide interindividual variation in the rates of metabolite formation.
Gondi N. Kumar, A. D. Rodrigues, A. Buko, J. Denissen   +3 more
semanticscholar   +1 more source

FRACTIONATION OF MOUSE LIVER MICROSOMAL ESTERASES

Canadian Journal of Biochemistry, 1965
Mouse liver microsomal esterases were fractionated on DEAE-cellulose after the solution of these enzymes in a solution containing 0.1 M glycyl glycine buffer, pH 7.0, and 5 × 10−4 M Lubrol W, a nonionic detergent. Elution of the enzymes from the DEAE-cellulose was accomplished by using NaCl in the glycyl glycine – Lubrol W solution.
C, CARRUTHERS, E, HEINS, A, BAUMLER
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Mechanism of reduction of nitrofurantoin on liver microsomes

Pharmacological Research Communications, 1980
Summary Reduction of the nitro-group of nitrofurantoin /N-[5-Nitro-2-furfuryliden-] 1-aminohydantoin/ on liver microsomes is supported both by NADPH and NADH. The site of interaction of nitrofurantoin with microsomes appears to be on two flavoproteins, NADPH-cytochrome P450 reductase and NADH-cytochrome b5 reductase; interaction with the former ...
Leskovac, Vladimir, Popović, Mira
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THE MECHANISM OF SCHRADAN ACTIVATION BY LIVER MICROSOMES

Canadian Journal of Biochemistry and Physiology, 1957
The mechanism by which schradan is converted to a powerful anticholinesterase by fortified liver homogenates has been studied. A scheme is proposed involving the production from DPNH of hydrogen peroxide, which then oxidizes an unknown microsomal factor with the aid of catalase. The factor in turn oxidizes schradan.
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