Results 211 to 220 of about 1,906,831 (271)
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The lipid composition of human liver microsomes
Lipids, 1982AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
L, Waskell, D, Koblin, E, Canova-Davis
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Mannosyltransfer reactions in rabbit liver microsomes
Biochemical and Biophysical Research Communications, 1976Abstract Rabbit liver microsomes catalyzed mannosyltransfer from GDP-[14C]mannose to free D -mannose resulting in the synthesis of α-1,2-, α-1,3-, and α-1,6-mannosyl-mannose. Whereas formation of α-1,2-mannosyl-mannose was stimulated by the addition of manganese chloride or nickel chloride and was inhibited by EDTA, synthesis of α-1,3-mannosyl ...
J S, Schutzbach, A K, Verma
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Interaction of piperine with rat liver microsomes
Toxicology, 1987Pretreatment of adult male albino rats with piperine did not induce cytochrome P-450 whereas safrole did cause such induction. Piperine and safrole interacted with different forms of cytochrome P-450 as indicated by their in vivo effect on drug metabolising enzymes and mixed function oxidases and electrophoretic patterns.
B G, Bhat, N, Chandrasekhara
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Kavalactone Metabolism in Rat Liver Microsomes
Phytotherapy Research, 2011The specific CYP enzymes involved in kavalactone (KLT) metabolism and their kinetics have not been fully examined. This study used rat liver microsomes (RLM) to determine kavain (KA), methysticin (MTS) and desmethoxyyangonin (DMY) enzyme kinetic parameters, to elucidate the major CYP450 isoforms involved in KLT metabolism and to examine gender ...
Shuang, Fu, Anthony, Rowe, Iqbal, Ramzan
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Metabolism of diazinon by fish liver microsomes
Bulletin of Environmental Contamination and Toxicology, 1972The results of these experiments indicate that thein vitro metabolism of diazinon is accomplished by enzyme preparations from fish liver homogenates, with the microsomal fraction being most active. The enzyme system responsible for diazinon metabolism in channel catfish liver microsomes required NADPH and oxygen for the oxidative desulfuration of ...
J W, Hogan, C O, Knowles
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Activation of slaframine by liver microsomes and flavins
Biochemical Pharmacology, 1971Abstract Liver homogenates, in the presence of NADPH, are capable of activating slaframine to a form capable of stimulation in vitro of the guinea pig ileum. Activation activity has been located in the microsomal fraction and required NADPH; however, the reaction was not inhibited by carbon monoxide.
T E, Spike, S D, Aust
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Metabolism of lofepramine by rat liver microsomes
Xenobiotica, 19821. The metabolism of lofepramine in vitro by rat liver microsomes was studied. The enzyme system involved was dependent on cytochrome P-450 and the main metabolites were desmethylimipramine (DMI), formaldehyde and p-chlorobenzoic acid. 2. Microsomes from rats pretreated with phenobarbital or 3-methylcholanthrene showed enhanced lofepramine metabolizing
P O, Gunnarsson +3 more
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In Vitro Drug Metabolism Using Liver Microsomes
Current Protocols in Pharmacology, 2016K. Knights +3 more
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Oxidation of styrene in liver microsomes
Biochemical Pharmacology, 1969K C, Leibman, E, Ortiz
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