Results 231 to 240 of about 154,170 (305)

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

IMT504 accelerates post-hepatectomy liver regeneration in mice with involvement of GLAST + Wnt1 + bone marrow stromal progenitors. [PDF]

Sci Rep
Borda M, Cafaro L, Sierra R, Díaz Pedraza M, Becerra C, Ábalo A, Karolewski MJ, Cantero MJ, Schiavone M, Mazzolini GD, Montaner A, Fiore EJ, Aquino JB.   +12 more
europepmc   +1 more source

Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy

Yan Cui, Li Li, Yu He, Shan Shan, Lin Liu, Jiangbo Ren, Hui Wang, Miaoran Yang, Xinyan Zhao, Jidong Jia, Ping Wang   +10 more
openalex   +1 more source

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Nanoemulsion based on natural components enables oral liver-targeting delivery of Schizandrol B to enhance liver regeneration after hepatectomy in hepatocellular carcinoma. [PDF]

Regen Biomater
Chen Y, Xu J, Huang J, He H, Cheng Z, Zhou Z, Zhang M, Huang Y, Huang C, Peng J, Zhang S, Sun R, Gong Z.   +12 more
europepmc   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

Liver regeneration-associated machine learning architecture integrating time-phased predictions for post-hepatectomy liver failure. [PDF]

EClinicalMedicine
Shen H, Yuan T, Si A, Shen Y, Liu J, Jin L, Xie Z, Zhang H, Wei W, Dai Y, Jiang T, He C, Zhang S, Hu Y, Huang S, Yang Z, Chen Y, Zhang X, Shen F, Qi X, Li J.   +20 more
europepmc   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Assessment of hepatic steatosis during rat liver regeneration after 70% partial hepatectomy using stereology and MRI-PDFF. [PDF]

Sci Rep
Lund A, Kjaergaard U, Bertelsen L, Hansen ES, Andersen KH, Ringgaard S, Nyengaard JR, Laustsen C, Mortensen FV.   +8 more
europepmc   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source